DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and dyrk1b

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	XP_005158271.1	Gene:	dyrk1b / 556212	ZFINID:	ZDB-GENE-060503-499	Length:	833	Species:	Danio rerio

Alignment Length:	751	Identity:	232/751 - (30%)
Similarity:	338/751 - (45%)	Gaps:	174/751 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 IGSP-----------VSSSTTNSSNGGNERGSST--------------KSNSSSGSGSSGNSASS 150
            ||||           :.....:.|:.|.:..|||              ..:|.....|..|..|.
Zfish    27 IGSPDQNRFLPQSHLLRKPARSGSSSGCKPPSSTLCQPAALGFSPAEPTMSSQHSHPSFSNIHSM 91

  Fly   151 TGSGELKCNTPMTPSELVKKFRN----YLTDLEFEELKVYKEV--WYFGQHASKNYNKPAPTANT 209
            ....::..:..:....:...||:    .|..|..:.:|.||.:  .|:.:...:....|...::|
Zfish    92 ADQQQVLSDMTILQRRIPPSFRDPASAPLRKLSVDLIKTYKHINEVYYTKKKRRAQQVPPEDSST 156

  Fly   210 T------NLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKK 268
            .      |.||||||.:|.:...:....||||..:|||||||||::|.||.....||||||:|||
Zfish   157 KKERKVYNDGYDDDNYDYIVKNGEKWLDRYEIDSLIGKGSFGQVVKAYDHHEQEWVAIKIIKNKK 221

  Fly   269 RFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSM 333
            .|||||.:||.:|:.:.:.|.:..:.::|:..:..||.|||:.|||:|.|||:|::..|:.|.|:
Zfish   222 AFLNQAQIELRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSL 286

  Fly   334 SLIRRFCNSIVKCLRLLY----KENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYI 394
            :|.|:|...:  |..||:    :.:|||||||||||||.....|:||::||||||.:.::||.||
Zfish   287 NLTRKFAQQL--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYI 349

  Fly   395 QSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISV 459
            ||||||||||:||:.|..|||||||||||.|::||.|||.|.|||:|:..|:||||:||..::..
Zfish   350 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGVPPNHMLDQ 414

  Fly   460 ARRRRLFFD-----------SRDAPRCITNTKGRKRSPGSKSLAHIL----------------H- 496
            |.:.|.:||           ::|..:.:..:....:.|.::.|..||                |
Zfish   415 APKARKYFDKLSDGLWTVKKNKDIKKVLYPSASEYKPPATRRLHEILGVETGGPGGRRAGEQGHA 479

  Fly   497 -CQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ----------------PSASSRHRSCRMSS 544
             |....|.|.:.|.|::||..|:||..|..|.|.:                |:....|.:...||
Zfish   480 PCDYLKFKDLILRMLDYDPKTRITPFYALQHNFFKKTTDEGTNTSSSTSTSPAMDHSHSTSTTSS 544

  Fly   545 SSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQP--PSQSHGHA 607
            .|||.|.:..|..:..|.:|                 ...:|:|:..|....|.|  |||.....
Zfish   545 VSSSGGSSGSSNDNRNYRYS-----------------NRYYNSAVTHTDYEMQSPQAPSQQQLRI 592

  Fly   608 QSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVGSGSTHHVSSAATR 672
            ...|.            :||      .::::|.|| .|..|..||:      ..:|.|      .
Zfish   593 WPGGD------------SSM------GQLSNSGSD-SSYPQLLLHK------PAATQH------S 626

  Fly   673 KHLPGTGSGIVGAMSSKYGSSTLAHNHH-------------NVTHHNAS-----TATIATTTHH- 718
            :|..|.    :|.|...:....:..:||             |.....||     ||.:..::..
Zfish   627 RHFLGN----IGGMMEPHHPHPIYGSHHSNGRQLRQQQQQQNQPQGQASQGQQGTALMPVSSPQM 687

  Fly   719 ---------HHHHGGQ----QQQQSSSGASTMAMSH 741
                     ||||.||    |...||..:|....|:
Zfish   688 QDSIELSLTHHHHLGQSSIMQPPPSSLDSSQYGSSN 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	160/383 (42%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	146/328 (45%)
dyrk1b	XP_005158271.1	PKc_DYRK1	175..518	CDD:271128	148/344 (43%)
dyrk1b	XP_005158271.1	S_TKc	186..513	CDD:214567	146/328 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840