DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and dyrk3

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	XP_012815970.1	Gene:	dyrk3 / 493520	XenbaseID:	XB-GENE-1008699	Length:	568	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	226/471 - (47%)
Similarity:	316/471 - (67%)	Gaps:	36/471 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 NNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKK 170
            :.|..:|:.|:|:.:...       ..||..||..||:|.:|.||..|.:.   |.:||.:.||:
Frog    76 SGNRRVGAGVTSTESAFP-------LLTKEKSSDSSGTSKSSDSSAKSSKA---TYLTPDQAVKQ 130

  Fly   171 FRNYLTDLEFEELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEI 235
            :::.|:..|.:|:..:.|:::.|.:|.|   :........|.|||||.|.|.::.|||:|:|||:
Frog   131 YKHQLSAYELQEISSFSEIYFVGPNAKK---RQGVVGGPNNGGYDDDQGGYNLVPHDHVAYRYEV 192

  Fly   236 LEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLD 300
            |:||||||||||.:..|||.:.|:|:|::||:|||..||..|:.||:.|:::|..||.||||||:
Frog   193 LKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLE 257

  Fly   301 YTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENI 365
            ...||.|:|:||||:|:|||||||:|.:.|||:.|:|:|.:||::||..||:..|||||||||||
Frog   258 SFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKIIHCDLKPENI 322

  Fly   366 LLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGF 430
            ||||:|.|.||||||||||:..:::||||||||||:||||||.:||..|||||.||||.||.||:
Frog   323 LLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFGCILVELLTGY 387

  Fly   431 PLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNT---------------K 480
            ||||||:|.:||||:||:||.||..|:..|:|.:.|.:|:..||..|.|               :
Frog   388 PLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGTTVLNGSRSRR 452

  Fly   481 GRKR-SPGSKS-LAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFL-----QPSASSRHR 538
            |:.| :||||. :|.:..|:|..|||||:.||.|||..||||.:|..|:::     :||.:.:..
Frog   453 GKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRLPKPSVTEKAS 517

  Fly   539 SCRMSSSSSS-SGLNS 553
            ..|:||.:|| .|:.|
Frog   518 GKRISSQTSSFPGIGS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	194/359 (54%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	177/312 (57%)
dyrk3	XP_012815970.1	PKc_DYRK2_3	124..503	CDD:271126	200/381 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9984
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1618
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.000