DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and Hipk

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	213/921 - (23%)
Similarity:	350/921 - (38%)	Gaps:	298/921 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ENTVTTTSLNGNGNGNGNSNSNNNNN----------IGSPVSSSTTNS----SNGGNER------ 129
            :.|||.|:       :|..:......          :..|.:|::|:|    :....:|
  Fly    43 DQTVTATT-------DGTRHQEQQQQQLQQQQQQHILRQPATSASTSSVAAAATSKRKRQTDCDC 100

  Fly   130 GSSTKSNSSSGSGSSGNSASSTGSGEL--KCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYF 192
            |.....|||.|.....:|:::.|:|.:  |..:...|..:     ..::.|:....||...
  Fly   101 GCVDSYNSSHGPPVQQDSSAAAGAGSVGSKAGSGPGPDGI-----GPISSLKTAHTKVATS---- 156

  Fly   193 GQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHK 254
            |.||:..     |.:..::.|.|   |:|::::|:   .::..||:||.:|:|:||||::.....
  Fly   157 GGHANTQ-----PPSKRSSSGAD---GDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRG 213

  Fly   255 TNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNL 319
            |:..|||||::|...:..|..:|::||..|.:::|| ..|.:...:....:.|.|:.||::..||
  Fly   214 TSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNL 277

  Fly   320 YELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGS 382
            |:.:|:|.::...:..||.....::..|..|.:..:||.|||||||:|..  |....:|||||||
  Fly   278 YDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGS 342

  Fly   383 SCYVDRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIM 446
            :.:|.:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.
  Fly   343 ASHVSKTVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYIS 407

  Fly   447 EVLGLPPKVLISVARRRRLFF----DS---------RDAPRCITNTKGRKRSPGSKSLAHILHCQ 498
            :..|||.:.:::.|.:...||    ||         .:.....||||.:      ::..:|.:|.
  Fly   408 QTQGLPTEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSK------EARKYIFNCL 466

  Fly   499 D-----------------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF------------ 528
            |                       |.|||.|:|.|..|...|:||.||.:|.|
  Fly   467 DDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYC 531

  Fly   529 --------------------LQPSA-----------------------SSRHRSCRMSSSSSSSG 550
                                :||::                       |...|..|.....:..|
  Fly   532 NNVKASVQMMEVCRRGDFHTVQPASTLVTNFVPSSTENMTFTINNQLTSQVQRLVRDGRPLAYEG 596

  Fly   551 LNSVSQKSS----------------------CYSFSEISPG-----------------------T 570
            |..:....|                      |....:..|.                       .
  Fly   597 LYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVVVGSATMQPPLQVPPQQYV 661

  Fly   571 NGPVVASITSTTA---------VHNAAIATTTKSRQQP-----PSQSHGHA-------------- 607
            |.||..|:...|:         |..:.:|.....||..     |.|:..|:
  Fly   662 NVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQAPAHSLIVDSTPLFNVEEI 726

  Fly   608 --QSNGHLP--DIK---------------LSASDKYNSMQKVAVRSKITSSVSDLE--------- 644
              :.:.:||  |:|               :...:|....|...|:.::..|....:
  Fly   727 YPKHHLNLPRNDLKKESPAHHIAKGNSYRVPRHEKKEHQQLSPVKKRVKESSPPHQQRYQRAAHV 791

  Fly   645 SVQQYSLHRIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHH--------- 700
            |.|.::.|..  ..|:||.:..|:.:.......:.|.||.      |||:.:|:||
  Fly   792 SPQYHAHHNC--NYGNGSGYSASAGSVVASSAASSSNIVN------GSSSSSHHHHVPVAHAQPY 848

  Fly   701 --NVTHHNASTATI-----------ATTTHHHHHHGGQQQQQSS-----------------SGAS 735
              :..||..|....           ....|.|..||.|...|||                 |..:
  Fly   849 SSSSGHHIVSNCNANGGAGGAVVYQQPPAHAHQQHGQQPHPQSSQHPQHVKQPTITIHDTPSPTA 913

  Fly   736 TMAMSHSQSTG 746
            .:.:|.|:..|
  Fly   914 VITISDSEDEG 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	129/416 (31%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	120/366 (33%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	119/334 (36%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460713
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870