Protein Alignment Dyrk2 and Hipk1

DIOPT Version :10

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: XP_063138349.1
• Gene: Hipk1 / 365895
• RGDID: 1304941
• Length: 1233
• Species: Rattus norvegicus
• Alignment Length: 544
• Identity: 158/544 - (29%)
• Similarity: 264/544 - (48%)
• Gaps: 86/544 - (15%)

  Fly   139 SGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHAS---KNY 200
            :.:.|||::|::|.... :..|..:...|::.::......:.||:.....|....:|..   :|.
  Rat   104 TAADSSGSAATATFQSS-QTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNR 167

  Fly   201 NKPAPTANTTNL----GYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTH 258
            ......|.||.:    ......|:|::::|:   .:...||:||.:|:|:||||.:.....|...
  Rat   168 TVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEI 232

  Fly   259 VAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELI 323
            |||||::|...:..|..:|::||..|..::|| .:|.:...:....:.|.|:.||::..|||:.:
  Rat   233 VAIKILKNHPSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFL 296

  Fly   324 KKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYV 386
            |:|.::...:..||.....:...|..|....:||.|||||||:|..  |....:|||||||:.:|
  Rat   297 KQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 361

  Fly   387 DRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 450
            .:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|
  Rat   362 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQG 426

  Fly   451 LPPKVLISVARRRRLFFDSRDAPRC------ITNTKGRKRSPGSKS---LAHILHCQD------- 499
            ||.:.|:|...:...|| :|| |..      :...:..:...|.||   ..:|.:|.|
  Rat   427 LPAEYLLSAGTKTTRFF-NRD-PNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 489

  Fly   500 ----------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH-RSCRM 542
                            |.:||.|::.|..|..:|:||.:..:|:|     |.....|.| :||..
  Rat   490 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQ 554

  Fly   543 SSSSSSSGL---NSVSQKSSCYSFSEISPGTNGPVVASITS-TTAVHN---------------AA 588
            :.......:   ::|||..|.:: :.::|.|:..:..|.:: .:.|||               ||
  Rat   555 NMEICKRRVHMYDTVSQIKSPFT-THVAPSTSTNLTMSFSNQLSTVHNQVLSNQASVLASSSTAA 618

  Fly   589 IATTT-----------KSRQQPPS 601
            .||.:           :|...|||
  Rat   619 AATLSLANSDVSLLNYQSALYPPS 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	126/392 (32%)
Hipk1	XP_063138349.1	None