DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and Hipk1

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	XP_038958716.1	Gene:	Hipk1 / 365895	RGDID:	1304941	Length:	1216	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	158/544 - (29%)
Similarity:	264/544 - (48%)	Gaps:	86/544 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 SGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHAS---KNY 200
            :.:.|||::|::|.... :..|..:...|::.::......:.||:.....|....:|..   :|.
  Rat    87 TAADSSGSAATATFQSS-QTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNR 150

  Fly   201 NKPAPTANTTNL----GYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTH 258
            ......|.||.:    ......|:|::::|:   .:...||:||.:|:|:||||.:.....|...
  Rat   151 TVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEI 215

  Fly   259 VAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELI 323
            |||||::|...:..|..:|::||..|..::|| .:|.:...:....:.|.|:.||::..|||:.:
  Rat   216 VAIKILKNHPSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFL 279

  Fly   324 KKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYV 386
            |:|.::...:..||.....:...|..|....:||.|||||||:|..  |....:|||||||:.:|
  Rat   280 KQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 344

  Fly   387 DRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 450
            .:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|
  Rat   345 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQG 409

  Fly   451 LPPKVLISVARRRRLFFDSRDAPRC------ITNTKGRKRSPGSKS---LAHILHCQD------- 499
            ||.:.|:|...:...|| :|| |..      :...:..:...|.||   ..:|.:|.|
  Rat   410 LPAEYLLSAGTKTTRFF-NRD-PNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472

  Fly   500 ----------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH-RSCRM 542
                            |.:||.|::.|..|..:|:||.:..:|:|     |.....|.| :||..
  Rat   473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRVTPLKTLNHQFVTMTHLLDFPHSNHVKSCFQ 537

  Fly   543 SSSSSSSGL---NSVSQKSSCYSFSEISPGTNGPVVASITS-TTAVHN---------------AA 588
            :.......:   ::|||..|.:: :.::|.|:..:..|.:: .:.|||               ||
  Rat   538 NMEICKRRVHMYDTVSQIKSPFT-THVAPSTSTNLTMSFSNQLSTVHNQVLSNQASVLASSSTAA 601

  Fly   589 IATTT-----------KSRQQPPS 601
            .||.:           :|...|||
  Rat   602 AATLSLANSDVSLLNYQSALYPPS 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	126/392 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	117/335 (35%)
Hipk1	XP_038958716.1	STKc_HIPK1	174..528	CDD:271130	120/356 (34%)
Hipk1	XP_038958716.1	PHA03247	<623..930	CDD:223021	3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810