DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk2 and Clk2

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	XP_008759408.1	Gene:	Clk2 / 365842	RGDID:	1359711	Length:	540	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	116/365 - (31%)
Similarity:	198/365 - (54%)	Gaps:	42/365 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 FGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEH--DHIAFRYEILEVIGKGSFGQVIRALDHK 254
            |...:|::.::.|.:..      ||..|:  :|.|  |.:..||||:..:|:|:||:|::.:||:
  Rat   168 FSHSSSQHSSRRAKSVE------DDAEGH--LIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHR 224

  Fly   255 T-NTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLN 318
            . ...||:|||:|.:::...|.:|:|:|:::.|||.|..:..:.|.|:..:..|:||:|||:.|:
  Rat   225 RGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLS 289

  Fly   319 LYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL------------KQRG 371
            .::.:|.|||..:.:..:|.....:.:.::.|:...:.|.||||||||.            |:|.
  Rat   290 TFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRD 354

  Fly   372 -----SSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFP 431
                 |::::|:||||:.:......|.:.:|.||:|||||.|.:....|:||:|||:.|.|.||.
  Rat   355 ERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFT 419

  Fly   432 LFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSR-------DAPRCI-TNTKGRKRSPGS 488
            ||...:..|.||.:..:||..|..:|...|:::.|:..|       .|.|.: .|.|..:|...|
  Rat   420 LFQTHDNREHLAMMERILGPVPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTS 484

  Fly   489 KSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEF 528
            ::..|      ....|.::..||::||:|:|..||..|.|
  Rat   485 EAEDH------HQLFDLIENMLEYEPAKRLTLGEALQHPF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	116/365 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	106/322 (33%)
Clk2	XP_008759408.1	PKc_CLK2	190..519	CDD:271117	110/337 (33%)
Clk2	XP_008759408.1	S_TKc	203..519	CDD:214567	106/322 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810