DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and Hipk2

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001102092.1	Gene:	Hipk2 / 362342	RGDID:	1309349	Length:	1195	Species:	Rattus norvegicus

Alignment Length:	802	Identity:	213/802 - (26%)
Similarity:	343/802 - (42%)	Gaps:	179/802 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 GNGNGNSNSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSNSSSGSGSSGN----SASSTG-SGEL 156
            |.|:.:...:.:.||.....:|||.|::......|.....:....||:|:    |||||. :|::
  Rat    43 GYGSHSKVYSQSKNIPPSQPASTTVSTSLPIPNPSLPYEQTIIFPGSTGHIVVTSASSTSVTGQV 107

  Fly   157 KCNTPMTPSELVKKFRNYLTDL--------EFEELKVYKEVWYFGQHASKNYNKPA--------- 204
            ...    |..|:::....|.|.        :.||::....|....:|.....|..:
  Rat   108 LGG----PHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATT 168

  Fly   205 PTANTTNLGYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRN 266
            .||.:.|.| .:..|:|::::|:   .:...||:||.:|:|:||||::.....||..|||||::|
  Rat   169 STATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 232

  Fly   267 KKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGF 331
            ...:..|..:|::||..|..:.|| .:|.:...:....:.|.|:.||::..|||:.:|:|.::..
  Rat   233 HPSYARQGQIEVSILARLSTESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPL 296

  Fly   332 SMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL--KQRGSSSIKVIDFGSSCYVDRKI-YTY 393
            .:..||.....:...|..|....:||.|||||||:|  ..|....:|||||||:.:|.:.: .||
  Rat   297 PLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTY 361

  Fly   394 IQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLIS 458
            :|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|||.:.|:|
  Rat   362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLS 426

  Fly   459 VARRRRLFF----------------DSRDAPRCITNTKGRKRSPGSKSLAHILHCQD-------- 499
            ...:...||                |..:|...|.:.:.||         :|.:|.|
  Rat   427 AGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARK---------YIFNCLDDMAQVNMT 482

  Fly   500 ---------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF------LQPSASSRHRSCRMS 543
                           |.|||.|::.|..|..:|:||.|..:|.|      |....|:..:||..:
  Rat   483 TDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQN 547

  Fly   544 SSSSSSGLN---SVSQKSSCYSFSEISPGTNGPVVASITST-----TAVHNAAIATTTKSRQ-QP 599
            .......:|   :|:|..:.: .:.::|.|:    .::|.|     |.|||.|..:|:.:.. ..
  Rat   548 MEICKRRVNMYDTVNQSKTPF-ITHVAPSTS----TNLTMTFNNQLTTVHNQAPTSTSATLSLAN 607

  Fly   600 PSQSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRS-KITSSVSDL----ESVQQY---------- 649
            |..|..:.||..:.|    ||:    ||..||.|| .:.:..:.:    :..||.
  Rat   608 PEVSILNYQSTLYQP----SAA----SMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQG 664

  Fly   650 -----SLHRIYGGVGSGSTHHVSSAATRKHL-----------PGTGSGIVGAMSSKYGSSTLAHN 698
                 |.|..|......:...|:.|...:.|           ||....|:  :...:...|....
  Rat   665 LQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQAWPGGAQQIL--LPPAWQQLTGVAT 727

  Fly   699 HHNVTHHNASTATIATT--------THHHHHHGG----------------------------QQQ 727
            |.:|.|......|:|.|        ||.|..|..                            .:|
  Rat   728 HTSVQHAAVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQ 792

  Fly   728 QQSSSGASTMAMSHSQSTGDVS 749
            |.:|:.:|..:..|..|..:||
  Rat   793 QPTSTTSSRKSKQHQSSARNVS 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	129/402 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	119/343 (35%)
Hipk2	NP_001102092.1	STKc_HIPK2	183..537	CDD:271129	122/363 (34%)
Hipk2	NP_001102092.1	S_TKc	199..527	CDD:214567	118/337 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810