Protein Alignment Dyrk2 and mnb

DIOPT Version :10

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Alignment Length: 750
• Identity: 243/750 - (32%)
• Similarity: 349/750 - (46%)
• Gaps: 196/750 - (26%)

  Fly   115 VSSSTTNSSNGGNER---------GSSTKS-NSSSGSGSSG------------------------ 145
            |..|:::||....||         |||..| :::.||||.|
  Fly   139 VQGSSSSSSRMKAERALYYTMSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRD 203

  Fly   146 ---NSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYK---EVWYF----------GQ 194
               :.:|.:.|.|::......|:...:.....|..|..:.:|.||   ||:|.          |.
  Fly   204 VMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGD 268

  Fly   195 HASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHV 259
            ..|.|..:    ....|.||||||.:|.|...:....||||..:|||||||||::|.||:...||
  Fly   269 DDSSNKKE----RKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHV 329

  Fly   260 AIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIK 324
            |||||:|||.|||||.:|:.:|:.:...||:..:.::.:..:..:|.|||:.|||:|.|||:|::
  Fly   330 AIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLR 394

  Fly   325 KNNYNGFSMSLIRRFCNSIVKCLRLLY----KENIIHCDLKPENILLKQRGSSSIKVIDFGSSCY 385
            ..|:.|.|::|.|:|...:  |..||:    :.||||||||||||||.....|:||::||||||.
  Fly   395 NTNFRGVSLNLTRKFAQQL--CTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 457

  Fly   386 VDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 450
            :.::||.||||||||||||:||:||..|||||||||||.|::||.|||.|.|||:|:..|:||||
  Fly   458 LGQRIYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLG 522

  Fly   451 LPPKVLISVARRRRLFFDSRDAPRCIT---NTKGRK-RSPGSKSLAHIL---------------- 495
            :|||.|:..|.:.|.|||...|.....   |..||| :.|||:.|..||
  Fly   523 MPPKYLLDQAHKTRKFFDKIVADGSYVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPG 587

  Fly   496 HCQDRY--FIDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKS 558
            |....|  |.|.:.|.|::||..|:||..|..|.|.:.:|         ..::::||..:.:...
  Fly   588 HSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTA---------DEATNTSGAGATANAG 643

  Fly   559 SCYSFSEISPGTNGPVV-----ASITSTTAVHNAAIATTTKS----------------------- 595
            :..|.|..:.|::|..|     ||.:|:.||.:::.|..|.:
  Fly   644 AGGSGSSGAGGSSGGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAGSSGSGSSVGGGSSAA 708

  Fly   596 -RQQ------------PP---------SQSHG---HA--------------QSNGHLPDIKLSAS 621
             :||            ||         .|.||   |:              |||.|.|....::.
  Fly   709 QQQQAMPLPLPLPLPLPPLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSH 773

  Fly   622 DKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAM 686
            ...||:                                 ||.:|:|..:|..|...:.|......
  Fly   774 HSTNSL---------------------------------GSLNHISPGSTGCHNNNSNSSNNNTR 805

  Fly   687 SSK-YGSSTLAHNHHNVTHHNASTATIATTTHHHH 720
            .|: |||:.:    :.|.|||:.::....:..:.|
  Fly   806 HSRLYGSNMV----NMVGHHNSGSSNNHNSISYPH 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	174/381 (46%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	161/349 (46%)