Protein Alignment Dyrk2 and dyrk1ab

DIOPT Version :9

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_001334760.1
• Gene: dyrk1ab / 327466
• ZFINID: ZDB-GENE-030131-5677
• Length: 719
• Species: Danio rerio
• Alignment Length: 648
• Identity: 223/648 - (34%)
• Similarity: 319/648 - (49%)
• Gaps: 139/648 - (21%)

  Fly   175 LTDLEFEELKVYK---EVWYF--------GQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDH 228
            |..|..:.:|.||   ||:|.        ||....::.|.....|.   ||||:|.:|.:...:.
Zfish    55 LRKLSIDLIKTYKHINEVYYAKKKRRHQQGQGEDSSHKKERKVFND---GYDDENYDYVVKNGEK 116

  Fly   229 IAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSH 293
            ...||||..:|||||||||::|.|......||||||:|||.|||||.:|:.:|:.:.:.|.:..:
Zfish   117 WMDRYEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 181

  Fly   294 NVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLY----KEN 354
            .::|:..:..||.|||:.||::|.|||:|::..|:.|.|::|.|:|...:  |..||:    :.:
Zfish   182 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQL--CTALLFLATPELS 244

  Fly   355 IIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSL 419
            |||||||||||||.....|:||::||||||.:.::||.||||||||||||:||:.|..|||||||
Zfish   245 IIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSL 309

  Fly   420 GCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDS-RDAPRCITNTKGRK 483
            ||||.|::||.|||.|.|||:|:..|:||||:||..::.:|.:.|.||:. .|....|..||..|
Zfish   310 GCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPNHIMDLAPKARKFFEKLSDGTWSIKKTKDGK 374

  Fly   484 R--SPGSKSLAHIL----------------HCQDRY--FIDFLQRCLEWDPAERMTPDEAAHHEF 528
            |  .|.|:.|..||                |....|  |.|.:.|.|::||..|:.|..|..|.|
Zfish   375 RYKPPASRKLHAILGVECGGPGGRRAGESGHAVADYLKFKDLILRMLDYDPKTRIQPYYALQHSF 439

  Fly   529 LQPSASSRHRSCRMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTT 593
            .:.:..   .....|||.|:|.....||.|          ||     .|.||:::..::..:|:.
Zfish   440 FKKTTD---EGTNTSSSVSTSPALEQSQSS----------GT-----TSSTSSSSGGSSGTSTSG 486

  Fly   594 KSRQQPPSQSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHRIYGG- 657
            ::|..|   :|.|..|:||. ...:.|.|..|...               ::.|.|....::.|
Zfish   487 RARSDP---THHHRHSSGHF-GTAMPAIDCDNLCP---------------QARQPYHPPVVWPGI 532

  Fly   658 VG----SGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHHNVTHHNASTATIATTTHH 718
            ||    :..||.|..  |..|:|           .::..:...|:||   ||           ||
Zfish   533 VGPEPVTVETHPVQE--TTFHVP-----------PQHPKALHPHHHH---HH-----------HH 570

  Fly   719 HHHHG-----------------------------GQQQQQSSSGASTMAMSHSQSTGDVSDRA 752
            |||||                             |.....|.|.:::.:.:.|.|||:..::|
Zfish   571 HHHHGQVIATRPRPRLYNSPTNSASTQDSMEVVHGHLSMTSLSSSASSSSTSSSSTGNHGNQA 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	164/378 (43%)
		S_TKc	233..529	CDD:214567	148/320 (46%)
dyrk1ab	NP_001334760.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840