Protein Alignment Dyrk2 and Dyrk2

DIOPT Version :10

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_001101570.2
• Gene: Dyrk2 / 314862
• RGDID: 1312039
• Length: 600
• Species: Rattus norvegicus
• Alignment Length: 656
• Identity: 260/656 - (39%)
• Similarity: 355/656 - (54%)
• Gaps: 115/656 - (17%)

  Fly    25 RNGITGYKLLQSDLVWCPGIQLDNEKLRRDVRLSG------SRLDLPQLCNGSRRLDGHNNHVAA 83
            |.|.|..:.||:.    |||.....:       ||      |.:.||.|               .
  Rat    18 RGGDTAVRQLQAS----PGIGAGAPR-------SGVGTGPPSPIALPPL---------------R 56

  Fly    84 NENTVTTTSLNGNGNGNGN-------------------SNSNNNNNIGSPVSSSTTNSSNGGNER 129
            ..|..||:...|.|....|                   .|||....:.:..:..||....|....
  Rat    57 ASNATTTSHTIGGGKHTMNDHLHISHSHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVV 121

  Fly   130 GSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQ 194
            ......:.....|||.:..|..|.|::|. :||||.:.:|::...||..|..|:..|.|:::.|.
  Rat   122 PERQLESIHRRQGSSTSLKSMEGMGKVKA-SPMTPEQAMKQYIQKLTAFEHHEIFSYPEIYFLGP 185

  Fly   195 HASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHV 259
            :|.|   :...|....|.|||||.|:|..:.|||:|:|||:|:||||||||||::|.|||.:.||
  Rat   186 NAKK---RQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHV 247

  Fly   260 AIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIK 324
            |:|::||:|||..||..|:.||:.||::|.|.:.||||||:...||.|:|:||||:|:|||||||
  Rat   248 ALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIK 312

  Fly   325 KNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRK 389
            ||.:.|||:.|:|:|.:||::||..|:|..|||||||||||||||:|.|||||||||||||..::
  Rat   313 KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQR 377

  Fly   390 IYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPK 454
            :||||||||||:||||||.:||..|||||||||||||.||:||.|||:|.:||||::|:||:|.:
  Rat   378 VYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQ 442

  Fly   455 VLISVARRRRLFFDSRDAPRCITNTK----------GRKR------SPGSKSLAHILH-CQDRYF 502
            .|:..::|.:.|..|:..||..|.|.          ||.|      .|.|:...:.|. |.|..|
  Rat   443 KLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLF 507

  Fly   503 IDFLQRCLEWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKSSCYSFSEIS 567
            :|||::|||||||.||||.:|..|.:|      |.|..:..:...::
  Rat   508 LDFLKQCLEWDPAVRMTPGQALRHPWL------RRRLPKPPTGEKTA------------------ 548

  Fly   568 PGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPDIKLSASDKYNSMQKVAV 632
                   |..:|.:|.      |.|:.|:..|||.|....::|      ....:|...::|:..|
  Rat   549 -------VKRVTESTG------AITSISKLPPPSSSASKLRTN------LAQMTDANGNIQQRTV 594

  Fly   633 RSKITS 638
            ..|:.|
  Rat   595 LPKLVS 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	199/359 (55%)
Dyrk2	NP_001101570.2	PKc_DYRK2_3	155..534	CDD:271126	210/395 (53%)