Protein Alignment Dyrk2 and Hipk4

DIOPT Version :9

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_001019947.1
• Gene: Hipk4 / 308449
• RGDID: 1307541
• Length: 616
• Species: Rattus norvegicus
• Alignment Length: 602
• Identity: 166/602 - (27%)
• Similarity: 248/602 - (41%)
• Gaps: 143/602 - (23%)

  Fly   233 YEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRN---KKRFLNQAVVELNILDELREKDADGSHN 294
            |:|:||:|||:||:|.:.....|...|||||::|   :.|.:..   ||.:|..:|..|.|.:|
  Rat    11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRSRIIKN---ELKLLRCVRGLDPDEAH- 71

  Fly   295 VIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCD 359
            ||..|::.:......:.|||:..||:|..|:||:.......||.....:::.|..|.:..|||.|
  Rat    72 VIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLRALARLKELAIIHAD 136

  Fly   360 LKPENILL--KQRGSSSIKVIDFGSSCYVDRKIYT---YIQSRFYRSPEVILGLQYGTAIDMWSL 419
            ||||||:|  :.|....:|||||||:.......|.   ||||||||:||::|||.:...:|:|||
  Rat   137 LKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSL 201

  Fly   420 GCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRC--------- 475
            ||::|||:.|:||:||.||.:|:..|.|..|||...|:..||:...||.....|..
  Rat   202 GCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAARKAHHFFKRNPHPDATNPWQLKSS 266

  Fly   476 ---ITNTKGR---KRSPGSKSLAHI---------------------LHCQDRYFIDFLQRCLEWD 513
               :..||.|   :|....|||..|                     .|...:..::.::|.|.|:
  Rat   267 ADYLAETKVRPLERRKYMLKSLDQIETVNGGGAVNRLSFPDREALAEHADLKSMVELIKRMLTWE 331

  Fly   514 PAERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKSSCYSFS----EISPGTNG-- 572
            ..||::|..|..|.|:                 |...|.|..:.:..|..|    .:|...:|
  Rat   332 SHERISPSAALRHPFV-----------------SMQQLRSAHEATRYYQLSLRGCRLSLQVDGKP 379

  Fly   573 --PVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPDIKLSAS----DKYNSMQKVA 631
              ||:|:                 :...||.......:....|..:..|.|    ||...||:.
  Rat   380 PPPVIAN-----------------AEDGPPYYRLAEEEETAGLGGVTGSGSFFREDKAPGMQRA- 426

  Fly   632 VRSKITSSVSDLESVQQYSLHRIYGGVGSGSTHHVSS--------AATRKHLPGTGSGIVGAMSS 688
                       ::.:...||.....|:.|.:...:.|        |.|...:|.:|...:.|.
  Rat   427 -----------IDQLDDLSLQEARRGLWSDTRADMVSDMLAPLKVATTSHRVPDSGPEPILAF-- 478

  Fly   689 KYGSSTLAHNHHNVTHHNASTATIATTTHHHHHHGGQQQQQSSSGASTMAMS-------HSQST- 745
             |||....       .|.|..|...:.:..:..:..:..|.|...|.:...|       |:.||
  Rat   479 -YGSRLTG-------RHKARKAPAGSKSDSNFSNLIRLSQASPEDAGSCRGSGWEEGEGHTTSTE 535

  Fly   746 --------GD---VSDR 751
                    ||   :.||
  Rat   536 PSAIPQREGDGPSIKDR 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	119/339 (35%)
		S_TKc	233..529	CDD:214567	119/339 (35%)
Hipk4	NP_001019947.1	PKc_like	11..347	CDD:419665	119/339 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	487..616		14/66 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810