Protein Alignment Dyrk2 and ppk15

DIOPT Version :10

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_593830.1
• Gene: ppk15 / 2542228
• PomBaseID: SPAC823.03
• Length: 534
• Species: Schizosaccharomyces pombe
• Alignment Length: 516
• Identity: 179/516 - (34%)
• Similarity: 270/516 - (52%)
• Gaps: 89/516 - (17%)

  Fly   120 TNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFR--------NYLT 176
            :|:.........|.::|.:....|||.:..:          |:.|:  .||:.        :|::
pombe    11 SNNPPAARTHDHSQRNNHARHVSSSGTTLFA----------PVKPA--TKKYNYRRVSPHGSYIS 63

  Fly   177 DLEFEELKVYKEVWY------FGQHASKNYNKP--APTANTTNLGYDDDNGNYKIIEHDHIAF-- 231
            .||...:|:...  |      |...:.:|..:|  .|:....|.|:|:.|.:|.:..:|.:..
pombe    64 PLEAMTVKLADT--YSICNPKFQFSSEQNPRRPLTKPSEGVHNHGFDNVNHDYVLYVNDLLGTDE 126

  Fly   232 --RYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREK-DADGSH 293
              :|.||:.:|.|:||||.|..|.||...||||:|:||..|.||.|:|::||:.|..| |.:...
pombe   127 GRKYLILDTLGHGTFGQVARCQDLKTQQIVAIKVIKNKPAFYNQCVMEVSILELLNNKYDPEDKR 191

  Fly   294 NVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHC 358
            ::|.:.|....:.|||:.|||:|:|||||||:|.:.|..:||:|.|...::.|..||.:..||||
pombe   192 HLIRLYDQFMHKNHLCLVFELLSINLYELIKQNQFRGLHLSLVRSFATQLLSCTSLLKQARIIHC 256

  Fly   359 DLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCIL 423
            |||||||||:...|..:|||||||:|:..:.:||||||||||||||||||.|...||||||||||
pombe   257 DLKPENILLQDLSSPIVKVIDFGSACHERQTVYTYIQSRFYRSPEVILGLHYNCGIDMWSLGCIL 321

  Fly   424 AELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDS------------------- 469
            |||:.|.|||||.:|..||..|:::||.||..::.:.:..:.:::|
pombe   322 AELFLGLPLFPGNSEYNQLCRIVDMLGNPPTWMLEMGKNSKKYYNSGFVNGRKTYELKSIEQFSI 386

  Fly   470 ---------------RDAPRCITNTKGRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMT 519
                           :.....:.|...||.:|   .|....|.:...||||:::.||.:|.:|.|
pombe   387 ENNKTEQPGKQYFGEKTLDAIVLNYPRRKTTP---KLTPEEHEERLCFIDFIKQFLELNPLKRWT 448

  Fly   520 PDEAAHHEFLQPSASSRHRSC-----------RMSSSSSSSGLNSV----SQKSSCYSFSE 565
            ||:|.:|.|:..::.|::  |           |..:.|.:.|..:|    .|::|.|..:|
pombe   449 PDQAKNHPFITGASFSQY--CIDKQKPLLTTQRTRNRSHTIGNQAVVPPSLQRASTYVSNE 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	154/389 (40%)
ppk15	NP_593830.1	PKc_YAK1	130..458	CDD:271114	143/330 (43%)