DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and ppk15

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_593830.1	Gene:	ppk15 / 2542228	PomBaseID:	SPAC823.03	Length:	534	Species:	Schizosaccharomyces pombe

Alignment Length:	516	Identity:	179/516 - (34%)
Similarity:	270/516 - (52%)	Gaps:	89/516 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 TNSSNGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFR--------NYLT 176
            :|:.........|.::|.:....|||.:..:          |:.|:  .||:.        :|::
pombe    11 SNNPPAARTHDHSQRNNHARHVSSSGTTLFA----------PVKPA--TKKYNYRRVSPHGSYIS 63

  Fly   177 DLEFEELKVYKEVWY------FGQHASKNYNKP--APTANTTNLGYDDDNGNYKIIEHDHIAF-- 231
            .||...:|:...  |      |...:.:|..:|  .|:....|.|:|:.|.:|.:..:|.:..
pombe    64 PLEAMTVKLADT--YSICNPKFQFSSEQNPRRPLTKPSEGVHNHGFDNVNHDYVLYVNDLLGTDE 126

  Fly   232 --RYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREK-DADGSH 293
              :|.||:.:|.|:||||.|..|.||...||||:|:||..|.||.|:|::||:.|..| |.:...
pombe   127 GRKYLILDTLGHGTFGQVARCQDLKTQQIVAIKVIKNKPAFYNQCVMEVSILELLNNKYDPEDKR 191

  Fly   294 NVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHC 358
            ::|.:.|....:.|||:.|||:|:|||||||:|.:.|..:||:|.|...::.|..||.:..||||
pombe   192 HLIRLYDQFMHKNHLCLVFELLSINLYELIKQNQFRGLHLSLVRSFATQLLSCTSLLKQARIIHC 256

  Fly   359 DLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCIL 423
            |||||||||:...|..:|||||||:|:..:.:||||||||||||||||||.|...||||||||||
pombe   257 DLKPENILLQDLSSPIVKVIDFGSACHERQTVYTYIQSRFYRSPEVILGLHYNCGIDMWSLGCIL 321

  Fly   424 AELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDS------------------- 469
            |||:.|.|||||.:|..||..|:::||.||..::.:.:..:.:::|
pombe   322 AELFLGLPLFPGNSEYNQLCRIVDMLGNPPTWMLEMGKNSKKYYNSGFVNGRKTYELKSIEQFSI 386

  Fly   470 ---------------RDAPRCITNTKGRKRSPGSKSLAHILHCQDRYFIDFLQRCLEWDPAERMT 519
                           :.....:.|...||.:|   .|....|.:...||||:::.||.:|.:|.|
pombe   387 ENNKTEQPGKQYFGEKTLDAIVLNYPRRKTTP---KLTPEEHEERLCFIDFIKQFLELNPLKRWT 448

  Fly   520 PDEAAHHEFLQPSASSRHRSC-----------RMSSSSSSSGLNSV----SQKSSCYSFSE 565
            ||:|.:|.|:..::.|::  |           |..:.|.:.|..:|    .|::|.|..:|
pombe   449 PDQAKNHPFITGASFSQY--CIDKQKPLLTTQRTRNRSHTIGNQAVVPPSLQRASTYVSNE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	154/389 (40%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	143/330 (43%)
ppk15	NP_593830.1	PKc_YAK1	130..458	CDD:271114	143/330 (43%)
ppk15	NP_593830.1	S_TKc	130..458	CDD:214567	143/330 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740