DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and prp4

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_588261.1	Gene:	prp4 / 2539312	PomBaseID:	SPCC777.14	Length:	477	Species:	Schizosaccharomyces pombe

Alignment Length:	494	Identity:	148/494 - (29%)
Similarity:	228/494 - (46%)	Gaps:	79/494 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SRLDLPQLCNGSRRLDGHNNHVAANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSSN 124
            |.|.:|:     ::|....:.|:..:.......:..|.:....:...:|:|....|::|||:.|
pombe    34 SDLSIPE-----KKLKEDVDQVSTTKPIEAVPKMKTNASKIEINKEGSNSNTKLDVTNSTTSDS- 92

  Fly   125 GGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEV 189
                  .|.||:...........|.|......:.||....|.|.:.|    .|::        :.
pombe    93 ------PSIKSSVQIEDTEDDMFADSPSPSVKRQNTGKGISTLTRSF----ADMQ--------DN 139

  Fly   190 WYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHK 254
            |                        ||..|.||::..:.:..||.:...:|||.|..|:.|||..
pombe   140 W------------------------DDIEGYYKVVLMEELDSRYIVQSNLGKGMFSTVVSALDRN 180

  Fly   255 TNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNL 319
            .|...|||||||.:....:.:.|::||:.|:..|.:|..::||...:...:.|||:.||::||||
pombe   181 RNQTFAIKIIRNNEVMYKEGLKEVSILERLQAADREGKQHIIHYERHFMHKNHLCMVFEMLSLNL 245

  Fly   320 YELIKKNNYN-GFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGS- 382
            .:::||...| |.|:..:|.:...:...|.||.:.|:||.|:||:|:|:.:: .:.:|:.|.||
pombe   246 RDILKKFGRNVGLSIKAVRLYAYQMFMALDLLKQCNVIHSDIKPDNMLVNEK-RNILKICDLGSA 309

  Fly   383 SCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIME 447
            |...:.:|..|:.|||||:||:|||..|...||.||:||.|.|||||..||||....:.|..:||
pombe   310 SDASENEITPYLVSRFYRAPEIILGFPYSCPIDTWSVGCSLYELYTGQILFPGRTNNQMLRYMME 374

  Fly   448 VLGLPPKVLISVARRRRLFFDSRDA----------PRCITNTKGRKRSPGSK-------SLAHIL 495
            ..|   |....:.:|.:...|..||          |  |||.:.||....||       .|..:.
pombe   375 CKG---KFSHKMLKRSQFLNDHFDADFNFIQIDHDP--ITNQETRKPVKFSKPTKDIRSRLKEVP 434

  Fly   496 HCQDRYFI------DFLQRCLEWDPAERMTPDEAAHHEF 528
            ...|..||      |.|::|||.:|.:|:.|:.|..|.|
pombe   435 TSTDEEFIIRQELMDLLEKCLELNPEKRVPPEVALKHPF 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	124/368 (34%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	117/321 (36%)
prp4	NP_588261.1	STKc_PRP4	158..474	CDD:271037	118/322 (37%)
prp4	NP_588261.1	S_TKc	159..474	CDD:214567	117/321 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810