Sequence 1: | NP_001260456.1 | Gene: | Dyrk2 / 34831 | FlyBaseID: | FBgn0016930 | Length: | 757 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001356735.1 | Gene: | HIPK1 / 204851 | HGNCID: | 19006 | Length: | 1210 | Species: | Homo sapiens |
Alignment Length: | 512 | Identity: | 153/512 - (29%) |
---|---|---|---|
Similarity: | 256/512 - (50%) | Gaps: | 60/512 - (11%) |
- Green bases have known domain annotations that are detailed below.
Fly 139 SGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHAS---KNY 200
Fly 201 NKPAPTANTTNL----GYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTH 258
Fly 259 VAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELI 323
Fly 324 KKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYV 386
Fly 387 DRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 450
Fly 451 LPPKVLISVARRRRLFFDSRDAPRC------ITNTKGRKRSPGSKS---LAHILHCQD------- 499
Fly 500 ----------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH-RSCRM 542
Fly 543 SSSSSSSGL---NSVSQKSSCYSFSEISPGTNGPVVASITS-TTAVHNAAIATTTKS 595 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Dyrk2 | NP_001260456.1 | PKc_DYRK4 | 186..529 | CDD:271127 | 126/392 (32%) |
S_TKc | 233..529 | CDD:214567 | 117/335 (35%) | ||
HIPK1 | NP_001356735.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1084..1103 | ||
STKc_HIPK1 | 174..528 | CDD:271130 | 120/356 (34%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 835..856 | ||||
Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250 | 844..847 | ||||
Interaction with TP53. /evidence=ECO:0000269|PubMed:12702766 | 885..1093 | ||||
Required for localization to nuclear speckles. /evidence=ECO:0000250 | 891..998 | ||||
SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250 | 902..926 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 909..974 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1046..1069 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG0667 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R968 |
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
3 | 2.840 |