DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dyrk2 and HIPK1

DIOPT Version :9

Sequence 1:NP_001260456.1 Gene:Dyrk2 / 34831 FlyBaseID:FBgn0016930 Length:757 Species:Drosophila melanogaster
Sequence 2:NP_001356735.1 Gene:HIPK1 / 204851 HGNCID:19006 Length:1210 Species:Homo sapiens


Alignment Length:512 Identity:153/512 - (29%)
Similarity:256/512 - (50%) Gaps:60/512 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   139 SGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHAS---KNY 200
            :.:.|||::|:||.... :..|..:...|::.::......:.||:.....|....:|..   :|.
Human    87 TAADSSGSAATSTFQSS-QTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNR 150

  Fly   201 NKPAPTANTTNL----GYDDDNGNYKIIEHD---HIAFRYEILEVIGKGSFGQVIRALDHKTNTH 258
            ......|.||.:    ......|:|::::|:   .:...||:||.:|:|:||||.:.....|...
Human   151 TVVGAAATTTTVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEI 215

  Fly   259 VAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELI 323
            |||||::|...:..|..:|::||..|..::|| .:|.:...:....:.|.|:.||::..|||:.:
Human   216 VAIKILKNHPSYARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFL 279

  Fly   324 KKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYV 386
            |:|.::...:..||.....:...|..|....:||.|||||||:|..  |....:|||||||:.:|
Human   280 KQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHV 344

  Fly   387 DRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 450
            .:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||.:|.:|:..|.:..|
Human   345 SKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQG 409

  Fly   451 LPPKVLISVARRRRLFFDSRDAPRC------ITNTKGRKRSPGSKS---LAHILHCQD------- 499
            ||.:.|:|...:...|| :|| |..      :...:..:...|.||   ..:|.:|.|       
Human   410 LPAEYLLSAGTKTTRFF-NRD-PNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472

  Fly   500 ----------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH-RSCRM 542
                            |.:||.|::.|..|..:|:||.:..:|:|     |.....|.| :||..
Human   473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNHVKSCFQ 537

  Fly   543 SSSSSSSGL---NSVSQKSSCYSFSEISPGTNGPVVASITS-TTAVHNAAIATTTKS 595
            :.......:   ::|||..|.:: :.::|.|:..:..|.:: ...|||.|....:.|
Human   538 NMEICKRRVHMYDTVSQIKSPFT-THVAPNTSTNLTMSFSNQLNTVHNQASVLASSS 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dyrk2NP_001260456.1 PKc_DYRK4 186..529 CDD:271127 126/392 (32%)
S_TKc 233..529 CDD:214567 117/335 (35%)
HIPK1NP_001356735.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1084..1103
STKc_HIPK1 174..528 CDD:271130 120/356 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 835..856
Nuclear localization signal 1 (NLS1). /evidence=ECO:0000250 844..847
Interaction with TP53. /evidence=ECO:0000269|PubMed:12702766 885..1093
Required for localization to nuclear speckles. /evidence=ECO:0000250 891..998
SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250 902..926
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 909..974
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1069
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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