Protein Alignment Dyrk2 and Y111B2A.1

DIOPT Version :10

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_499631.2
• Gene: Y111B2A.1 / 190948
• WormBaseID: WBGene00013727
• Length: 385
• Species: Caenorhabditis elegans
• Alignment Length: 373
• Identity: 102/373 - (27%)
• Similarity: 159/373 - (42%)
• Gaps: 83/373 - (22%)

  Fly   210 TNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQA 274
            ||.|.|.:|                 :.|:|:|.||.|....|.:.....|:|:.:       ..
 Worm    44 TNWGTDLEN-----------------VSVLGEGVFGTVFEVADAEKKKKFALKLFK-------AG 84

  Fly   275 VVELNILDELRE----KDADGSH--NVIHM--------LDYTYFRKHLCITFELMSLNLYELIKK 325
            ..:....|.:||    |....:|  |:|.:        :...|.|  :.|..||...:|:.::..
 Worm    85 HTQFGCEDWVRESEIMKSVAAAHHPNLIKLVKSGKMASVPEGYLR--IAILMELRGKSLFSVMDS 147

  Fly   326 ------NNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENI-----------------LL 367
                  |....|.::.||.....|:..::.|.|..|:|.|||||||                 .:
 Worm   148 TKSEVPNKEISFPIATIREIGAQILSAMKKLEKMEIVHLDLKPENICFTSTCTFTTEIRKDVCYI 212

  Fly   368 KQRGSSSIKVIDFGS---SCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTG 429
            ......::.:||||:   |...|.|....:|::.||:||:.:||.:.|..|:||.||||:|||||
 Worm   213 SPSEELNVCIIDFGNARKSNQEDLKSSEVVQTQNYRAPEIFMGLPFSTRSDVWSFGCILSELYTG 277

  Fly   430 FPLFPG--ENEVEQLAC-IME-VLGLPPKVLISVARRRRLFFDSRDAPRCIT-NTKGRKRSPGSK 489
            ..||.|  |::.|||.. :|: :|...|..|:     .|...:::....||. |...:||:..|.
 Worm   278 ELLFYGNDEHDTEQLQFELMQLILQQAPSYLM-----MRKAAENKKKMICIDGNVYMKKRAKSSF 337

  Fly   490 SLAHILHCQ----DRYFI---DFLQRCLEWDPAERMTPDEAAHHEFLQ 530
            .....|:.|    ||..|   :.|:|.|.:||..|:|..|.:...|.:
 Worm   338 DPPLPLYKQRRRNDRAAIPLFELLERILIFDPTRRLTFSEISSETFFK 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	101/370 (27%)
Y111B2A.1	NP_499631.2	Protein Kinases, catalytic domain	56..>193	CDD:473864	35/145 (24%)
		Protein Kinases, catalytic domain	<130..384	CDD:473864	78/258 (30%)