DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and DYRK1A

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001387.2	Gene:	DYRK1A / 1859	HGNCID:	3091	Length:	763	Species:	Homo sapiens

Alignment Length:	671	Identity:	230/671 - (34%)
Similarity:	333/671 - (49%)	Gaps:	139/671 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 MTPSELVKKFRNYLT----DLEFEELKVYK---EVWYF--------GQHASKNYNKPAPTANTTN 211
            |....:.:.||:..|    .|..:.:|.||   ||:|.        ||....::.|.....|.
Human    76 MLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYND-- 138

  Fly   212 LGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVV 276
             ||||||.:|.:...:....||||..:|||||||||::|.|......||||||:|||.|||||.:
Human   139 -GYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI 202

  Fly   277 ELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCN 341
            |:.:|:.:.:.|.:..:.::|:..:..||.|||:.||::|.|||:|::..|:.|.|::|.|:|..
Human   203 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQ 267

  Fly   342 SIVKCLRLLY----KENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSP 402
            .:  |..||:    :.:|||||||||||||.....|:||::||||||.:.::||.||||||||||
Human   268 QM--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSP 330

  Fly   403 EVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFF 467
            ||:||:.|..|||||||||||.|::||.|||.|.|||:|:..|:||||:||..::..|.:.|.||
Human   331 EVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFF 395

  Fly   468 DS-RDAPRCITNTKGRKRS---PGSKSLAHIL----------------HCQDRY--FIDFLQRCL 510
            :. .|....:..||..||.   ||::.|.:||                |....|  |.|.:.|.|
Human   396 EKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRML 460

  Fly   511 EWDPAERMTPDEAAHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVV 575
            ::||..|:.|..|..|.|.:.:|.   .....|:|.|:|.....||.|          ||
Human   461 DYDPKTRIQPYYALQHSFFKKTAD---EGTNTSNSVSTSPAMEQSQSS----------GT----- 507

  Fly   576 ASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSV 640
            .|.||:::..::..:.:.::|..|   :|.|..|.||......:...:.:|.|   ||.:..:.:
Human   508 TSSTSSSSGGSSGTSNSGRARSDP---THQHRHSGGHFTAAVQAMDCETHSPQ---VRQQFPAPL 566

  Fly   641 --SDLESVQQYSL--HRIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHHN 701
              |..|:..|.::  |.:     ..:|.||:...             .|:...:|:|  :|:||
Human   567 GWSGTEAPTQVTVETHPV-----QETTFHVAPQQ-------------NALHHHHGNS--SHHHH- 610

  Fly   702 VTHHNASTATIATTTHHHHHHGGQQ-------------QQQSSSGASTMAMSH------------ 741
              ||           ||||||.|||             ...|||...:|.:.|
Human   611 --HH-----------HHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSST 662

  Fly   742 ------SQSTGDVSDRAIFGR 756
                  |.|||:..::|...|
Human   663 TSSSTSSSSTGNQGNQAYQNR 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	164/379 (43%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	147/321 (46%)
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..136		3/20 (15%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		3/16 (19%)
		PKc_DYRK1	148..484	CDD:271128	149/337 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..442		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..540		17/72 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..679		26/98 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..763
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840