Protein Alignment Dyrk2 and mbk-2

DIOPT Version :10

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_001023207.1
• Gene: mbk-2 / 178250
• WormBaseID: WBGene00003150
• Length: 817
• Species: Caenorhabditis elegans
• Alignment Length: 482
• Identity: 239/482 - (49%)
• Similarity: 316/482 - (65%)
• Gaps: 49/482 - (10%)

  Fly    88 VTTTSLNGNGN-----GNGNSNSNNNNNIGSP-----VSSSTTNSS------------NGGNERG 130
            |.|:|.||:.|     |:|.|.|....:||.|     .|.||.|::            :..||
 Worm   304 VGTSSSNGSSNSSSGVGSGGSGSLMTQSIGGPNKHLSASHSTLNTASTHDMMHSKIPKSPSNE-- 366

  Fly   131 SSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQH 195
            |.::|::||..||.|...|::||     |:...|.:.|:.|...|...|..|:..|..|::.|.|
 Worm   367 SLSRSHTSSSGGSQGGHNSNSGS-----NSGFRPEDAVQTFGAKLVPFEKNEIYNYTRVFFVGSH 426

  Fly   196 ASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVA 260
            |.|   :........|.||||:||:|:::.|||||:|||:|:|||||||||||:|.|||...:||
 Worm   427 AKK---QAGVIGGANNGGYDDENGSYQLVVHDHIAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVA 488

  Fly   261 IKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKK 325
            :|::||:|||..||..|:.|||.||.:|:||:||:||||||..||.|.||||||:|:|||||||:
 Worm   489 LKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKR 553

  Fly   326 NNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKI 390
            |.:.|||:.|:|:|..|::.||.||.|..:|||||||||:||||:|.|.||||||||||:.|::|
 Worm   554 NKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRI 618

  Fly   391 YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKV 455
            ||||||||||:||||||.:||..|||||||||||||.||:||.|||:|.:|||.|:|:||:||..
 Worm   619 YTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPK 683

  Fly   456 LISVARRRRLFFDSRDAPRCITNT---------------KGRKRS-PGSKSLAHIL-HCQDRYFI 503
            .:..|:|.|.|..|:..||..|.|               :|:.|. |.|:|.:..| :..|..|:
 Worm   684 SLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFV 748

  Fly   504 DFLQRCLEWDPAERMTPDEAAHHEFLQ 530
            |||:|||:|||..||||.:|..|::|:
 Worm   749 DFLKRCLDWDPETRMTPAQALKHKWLR 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	202/359 (56%)
mbk-2	NP_001023207.1	PKc_DYRK2_3	395..774	CDD:271126	208/381 (55%)