Sequence 1: | NP_001260456.1 | Gene: | Dyrk2 / 34831 | FlyBaseID: | FBgn0016930 | Length: | 757 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_034564.2 | Gene: | Hipk3 / 15259 | MGIID: | 1314882 | Length: | 1192 | Species: | Mus musculus |
Alignment Length: | 706 | Identity: | 190/706 - (26%) |
---|---|---|---|
Similarity: | 300/706 - (42%) | Gaps: | 151/706 - (21%) |
- Green bases have known domain annotations that are detailed below.
Fly 121 NSSNGGNE----RGSS-------TKSNSSSGSGSSGNSASSTGSGELKCNTPM-------TPSEL 167
Fly 168 VKKFRNYLTDLE----------FEEL-------KVYKEVWYFGQHASKNYNKPAPTANTTNLGYD 215
Fly 216 DD----NGNYKIIEHDHIAF---RYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQ 273
Fly 274 AVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRR 338
Fly 339 FCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVIDFGSSCYVDRKI-YTYIQSRFYR 400
Fly 401 SPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRL 465
Fly 466 FF----------------DSRDAPRCITNTKGRKRSPGSKSLAHILH----------------CQ 498
Fly 499 DRYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH-RSC----RMSSSSSSSGLNS 553
Fly 554 VSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQ-------------------- 598
Fly 599 -----PPS-----QSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDLESVQQYSLHR 653
Fly 654 IYGGVGSGSTHHVSSAATRKHLPG-------TGSGIVGAMS-SKYGSSTLAHNHHN 701 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Dyrk2 | NP_001260456.1 | PKc_DYRK4 | 186..529 | CDD:271127 | 125/389 (32%) |
S_TKc | 233..529 | CDD:214567 | 116/335 (35%) | ||
Hipk3 | NP_034564.2 | PKc_like | 196..525 | CDD:304357 | 115/331 (35%) |
S_TKc | 197..525 | CDD:214567 | 115/330 (35%) | ||
Interaction with AR. /evidence=ECO:0000250 | 767..921 | ||||
Interaction with FAS. /evidence=ECO:0000269|PubMed:11034606 | 775..868 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 799..829 | ||||
Required for localization to nuclear speckles. /evidence=ECO:0000250 | 832..988 | ||||
SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250 | 843..895 | ||||
Interaction with UBL1. /evidence=ECO:0000250 | 847..857 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 889..943 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 956..1023 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG0667 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R968 |
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
4 | 3.840 |