DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and CLK1

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001155879.1	Gene:	CLK1 / 1195	HGNCID:	2068	Length:	526	Species:	Homo sapiens

Alignment Length:	550	Identity:	157/550 - (28%)
Similarity:	240/550 - (43%)	Gaps:	106/550 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LQSDLVWCPGIQLDNEKLRRDVRLSGSRLDLPQLC--------------NGSRRLDGHNNHVAAN 84
            |:.||:   |.|...|.......|||.|......|              :.|.......:|.:|.
Human    20 LRGDLL---GFQNVREPSSCGETLSGMRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQ 81

  Fly    85 ENT--------------VTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSSNGGNERG--SST 133
            ||.              :.:.|:|       ..:.::...|....:..|.....|..:|.  |..
Human    82 ENKRCKYNHSKMCDSHYLESRSIN-------EKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRY 139

  Fly   134 KSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYFGQHASK 198
            :::||..||.||.|:..:                              :.:::....:...|...
Human   140 QNHSSKSSGRSGRSSYKS------------------------------KHRIHHSTSHRRSHGKS 174

  Fly   199 NYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKT-NTHVAIK 262
            :..|      .|....||:.|:......|.::.||||::.:|:|:||:|:..:|||. ..|||:|
Human   175 HRRK------RTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVK 233

  Fly   263 IIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNN 327
            |::|..|:...|..|:.:|:.|...|.:.:...:.||::.....|:||.|||:.|:.|:.||:|.
Human   234 IVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENG 298

  Fly   328 YNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRG-----------------SSSI 375
            :..|.:..||:....|.|.:..|:...:.|.||||||||..|..                 :..|
Human   299 FLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDI 363

  Fly   376 KVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVE 440
            ||:||||:.|.|....|.:.:|.||:|||||.|.:....|:||:||||.|.|.||.:||..:..|
Human   364 KVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKE 428

  Fly   441 QLACIMEVLGLPPKVLISVARRRRLFFDSR---DAPRCITNTKGRKRSPGSKSLAHILHCQD--- 499
            .||.:..:||..||.:|...|:|:.|...|   |.    .::.||..|...|.|...:..||
Human   429 HLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDE----HSSAGRYVSRRCKPLKEFMLSQDVEH 489

  Fly   500 -RYFIDFLQRCLEWDPAERMTPDEAAHHEF 528
             |.| |.:|:.||:|||:|:|..||..|.|
Human   490 ERLF-DLIQKMLEYDPAKRITLREALKHPF 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	126/367 (34%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	118/320 (37%)
CLK1	NP_001155879.1	PKc_CLK1_4	190..519	CDD:271115	120/333 (36%)
CLK1	NP_001155879.1	S_TKc	203..519	CDD:214567	118/320 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810