DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and HIPK3

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_005725.3	Gene:	HIPK3 / 10114	HGNCID:	4915	Length:	1215	Species:	Homo sapiens

Alignment Length:	717	Identity:	186/717 - (25%)
Similarity:	302/717 - (42%)	Gaps:	128/717 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 ENTVTTTSLNGNGNGNGNS-------------NSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSN 136
            |.....|.:||...||.:.             |....:|.....|:....::.|      :||..
Human    37 ERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAG------ATKVI 95

  Fly   137 SSSGSGSSGNSASSTGS---------GELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYF 192
            ::... .:...|...|:         |..:|.......||         |.....:::..|:...
Human    96 AAQAQ-QAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEEL---------DNHSSAMQIVDELSIL 150

  Fly   193 GQHASKNYNKPAPTANTTNLGYDDD----NGNYKIIEHDHIAF---RYEILEVIGKGSFGQVIRA 250
            ......|...|. |..|...|...:    .|:|::::|:.:..   .||:|:.:|:|:||||::.
Human   151 PAMLQTNMGNPV-TVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKC 214

  Fly   251 LDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELM 315
            ....||..|||||::|...:..|..:|::||..|..::|| .:|.:...:....|.|.|:.||::
Human   215 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-EYNFVRAYECFQHRNHTCLVFEML 278

  Fly   316 SLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVI 378
            ..|||:.:|:|.::...:.:||.....:...|:.|....:||.|||||||:|..  |....:|||
Human   279 EQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVI 343

  Fly   379 DFGSSCYVDRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQL 442
            ||||:.:|.:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||..|.:|:
Human   344 DFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQI 408

  Fly   443 ACIMEVLGLPPKVLISVARRRRLFF----------------DSRDAPRCITNTKGRKRSPGS-KS 490
            ..|.:..|||.:.|::|..:...||                :..:|...:.:.:.||....| ..
Human   409 RYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDD 473

  Fly   491 LAHILHCQD-------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH 537
            :||:....|             |.|:..|::.|..|...|:||.|..:|.|     |.....|.|
Human   474 VAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNH 538

  Fly   538 -RSCRMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPS 601
             :||........|.||      ||.:.:........||.:|.|:|...:...|.|.   |.|..:
Human   539 VKSCFHIMDICKSHLN------SCDTNNHNKTSLLRPVASSSTATLTANFTKIGTL---RSQALT 594

  Fly   602 QSHGHAQSNGHLP----DIKLSASDKYN--------SMQKV-AVRSKITS----------SVSDL 643
            .| .|:..:..:|    ..:....|.:.        ::|.: |...|.||          .|:..
Human   595 TS-AHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQA 658

  Fly   644 ESVQQYSLH-RIYGGVGSGSTHHVSSAATRKHLP-------GTGSGIVGA-MSSKYGSSTLAHNH 699
            .:||...:. .:.....||.|..:...|.::..|       .|...:.|: ....:|......||
Human   659 PAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNH 723

  Fly   700 HN 701
            :|
Human   724 YN 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	125/387 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	116/333 (35%)
HIPK3	NP_005725.3	STKc_HIPK3	196..525	CDD:271131	115/329 (35%)
		S_TKc	197..525	CDD:214567	115/328 (35%)
		Interaction with AR. /evidence=ECO:0000250	767..944
		Interaction with FAS. /evidence=ECO:0000250	796..891
		Required for localization to nuclear speckles. /evidence=ECO:0000250	855..1011
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	866..918
		Interaction with UBL1. /evidence=ECO:0000305	870..880
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840