DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk2 and dyrk2

DIOPT Version :9

Sequence 1:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	XP_002937581.2	Gene:	dyrk2 / 100485120	XenbaseID:	XB-GENE-854514	Length:	625	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	246/586 - (41%)
Similarity:	341/586 - (58%)	Gaps:	68/586 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SRLDLPQLCNGS-RRLDGHNNHVAANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSS 123
            |.:.||.|..|: ....|.|.| ..||:...|:............|||....:        |...
Frog    77 SPVSLPPLRTGNPTHTTGGNKH-TMNEHLHVTSHGQIQVQQLFEENSNKRTVL--------TTQP 132

  Fly   124 NGGNERGSST--------KSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEF 180
            ||....|.||        ..::....|||.:..|:.|..:|| ::.:||.:.:|::...||..|.
Frog   133 NGLTTVGKSTLPVVSERQLESTHRRQGSSSSLKSAEGITKLK-SSSLTPEQAMKQYMQKLTAFEH 196

  Fly   181 EELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFG 245
            .|:..|.|:::.|.:|.|   :........|.|||||.|:|..:.|||:|:|||:|:||||||||
Frog   197 HEIFNYPEIYFLGPNAKK---RQGVIGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFG 258

  Fly   246 QVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCI 310
            ||::|.|||.:.|||:|::||:|||..||..|:.||:.|:::|.|.:.||||||:...||.|:|:
Frog   259 QVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICM 323

  Fly   311 TFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSI 375
            ||||:|:|||||||||.:.|||:.|:|:|.:||::||..|:|..|||||||||||||||:|.|.|
Frog   324 TFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGI 388

  Fly   376 KVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVE 440
            ||||||||||..:::||||||||||:||||||.:||..|||||||||||||.||:||.|||:|.:
Frog   389 KVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGD 453

  Fly   441 QLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTK----------GRKR------SPGSK 489
            ||||::|:||:|.:.|:..::|.:.||.|:..||..|.|.          ||.|      .|||:
Frog   454 QLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVVLNGGRSRRGKLRGPPGSR 518

  Fly   490 SLAHILH-CQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ---PSASSRHRSCRMSSSSSSSG 550
            .....|. |.|..|:|||.:||||||:.||||.:|..|.:|:   |...:..:......:.|:..
Frog   519 DWVTALKGCDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLRRRLPKPPTGEKISTKRITESTGA 583

  Fly   551 LNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPD 615
            :.|:|:          .|.|:|......|:.|.:.:|                :|:.|....||.
Frog   584 ITSISK----------LPPTSGSAAKLRTNLTQITDA----------------NGNIQQRTVLPK 622

  Fly   616 I 616
            :
Frog   623 L 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	197/359 (55%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	179/312 (57%)
dyrk2	XP_002937581.2	PKc_DYRK2_3	180..559	CDD:271126	203/381 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9984
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1618
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.000