Protein Alignment Dyrk2 and dyrk2

DIOPT Version :10

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: XP_002937581.2
• Gene: dyrk2 / 100485120
• XenbaseID: XB-GENE-854514
• Length: 625
• Species: Xenopus tropicalis
• Alignment Length: 586
• Identity: 246/586 - (41%)
• Similarity: 341/586 - (58%)
• Gaps: 68/586 - (11%)

  Fly    60 SRLDLPQLCNGS-RRLDGHNNHVAANENTVTTTSLNGNGNGNGNSNSNNNNNIGSPVSSSTTNSS 123
            |.:.||.|..|: ....|.|.| ..||:...|:............|||....:        |...
 Frog    77 SPVSLPPLRTGNPTHTTGGNKH-TMNEHLHVTSHGQIQVQQLFEENSNKRTVL--------TTQP 132

  Fly   124 NGGNERGSST--------KSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKKFRNYLTDLEF 180
            ||....|.||        ..::....|||.:..|:.|..:|| ::.:||.:.:|::...||..|.
 Frog   133 NGLTTVGKSTLPVVSERQLESTHRRQGSSSSLKSAEGITKLK-SSSLTPEQAMKQYMQKLTAFEH 196

  Fly   181 EELKVYKEVWYFGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFG 245
            .|:..|.|:::.|.:|.|   :........|.|||||.|:|..:.|||:|:|||:|:||||||||
 Frog   197 HEIFNYPEIYFLGPNAKK---RQGVIGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFG 258

  Fly   246 QVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCI 310
            ||::|.|||.:.|||:|::||:|||..||..|:.||:.|:::|.|.:.||||||:...||.|:|:
 Frog   259 QVVKAYDHKLHQHVALKMVRNEKRFHRQAAEEIRILEHLKKQDKDNNMNVIHMLENFTFRNHICM 323

  Fly   311 TFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQRGSSSI 375
            ||||:|:|||||||||.:.|||:.|:|:|.:||::||..|:|..|||||||||||||||:|.|.|
 Frog   324 TFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGI 388

  Fly   376 KVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVE 440
            ||||||||||..:::||||||||||:||||||.:||..|||||||||||||.||:||.|||:|.:
 Frog   389 KVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGGRYGMPIDMWSLGCILAELLTGYPLLPGEDEGD 453

  Fly   441 QLACIMEVLGLPPKVLISVARRRRLFFDSRDAPRCITNTK----------GRKR------SPGSK 489
            ||||::|:||:|.:.|:..::|.:.||.|:..||..|.|.          ||.|      .|||:
 Frog   454 QLACMIELLGMPSQKLLDASKRGKNFFSSKGYPRYCTVTSLPDGSVVLNGGRSRRGKLRGPPGSR 518

  Fly   490 SLAHILH-CQDRYFIDFLQRCLEWDPAERMTPDEAAHHEFLQ---PSASSRHRSCRMSSSSSSSG 550
            .....|. |.|..|:|||.:||||||:.||||.:|..|.:|:   |...:..:......:.|:..
 Frog   519 DWVTALKGCDDPLFLDFLTQCLEWDPSLRMTPSQALRHHWLRRRLPKPPTGEKISTKRITESTGA 583

  Fly   551 LNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPSQSHGHAQSNGHLPD 615
            :.|:|:          .|.|:|......|:.|.:.:|                :|:.|....||.
 Frog   584 ITSISK----------LPPTSGSAAKLRTNLTQITDA----------------NGNIQQRTVLPK 622

  Fly   616 I 616
            :
 Frog   623 L 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	197/359 (55%)
dyrk2	XP_002937581.2	PKc_DYRK2_3	180..559	CDD:271126	203/381 (53%)