Protein Alignment Dyrk2 and dyrk1aa

DIOPT Version :9

• Sequence 1: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Sequence 2: NP_001074158.1
• Gene: dyrk1aa / 100005019
• ZFINID: ZDB-GENE-050302-29
• Length: 737
• Species: Danio rerio
• Alignment Length: 681
• Identity: 230/681 - (33%)
• Similarity: 340/681 - (49%)
• Gaps: 110/681 - (16%)

  Fly   109 NNIGSPVSSSTTNSS---NGGNERGSSTKSNSSSGSGSSGNSASSTGSGELKCNTPMTPSELVKK 170
            ::.|..:.:.|.:|.   :..:.:|::.:|.::..........|:|   ::..:..|....:.:.
Zfish    28 HSAGVQMDAQTPHSHPPFSDAHPQGAADQSAAALPYNPQAPQPSAT---QVTADMVMLQRRMPQC 89

  Fly   171 FRNYLT----DLEFEELKVYK---EVWYFGQHASKNYNKPAPTANTT-----NLGYDDDNGNYKI 223
            ||:..|    .|..|.:|.||   ||:|..:.......:...::|..     |.||||||.:|.:
Zfish    90 FRDPATAPLRKLSIELIKTYKHINEVYYAKKKRRHQQGQGEDSSNKKERKIYNDGYDDDNFDYIV 154

  Fly   224 IEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKD 288
            ...:....||||..:|||||||||::|.|......||||||:|||.|||||.:|:.:|:.:.:.|
Zfish   155 KNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHD 219

  Fly   289 ADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLY-- 351
            .:..:.::|:..:..||.|||:.||::|.|||:|::..|:.|.|::|.|:|...:  |..||:
Zfish   220 TEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQL--CTALLFLA 282

  Fly   352 --KENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAI 414
              :.:|||||||||||||.....|:||::||||||.:.::||.||||||||||||:||:.|..||
Zfish   283 TPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAI 347

  Fly   415 DMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSR-DAPRCITN 478
            |||||||||.|::||.|||.|.|||:|:..|:||||:||..::..|.:.|.||:.. |:..|...
Zfish   348 DMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGVPPSHILEQAPKARKFFEKMPDSMWCAKK 412

  Fly   479 TK-GRKRSP-GSKSLAHIL----------------HCQDRY--FIDFLQRCLEWDPAERMTPDEA 523
            || |::..| ||:.|..||                |....|  |.|.:.|.|::||..|:.|..|
Zfish   413 TKDGKRYKPAGSRKLHSILGVEAGGPGGRRAGESGHAVADYLKFKDLILRMLDYDPKTRIQPYYA 477

  Fly   524 AHHEFLQPSASSRHRSCRMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAA 588
            ..|.|.:.:|.   .....|||.|:|.....||.|          ||     .|.||:::..::.
Zfish   478 LQHSFFKKTAD---EGTNTSSSVSTSPALEQSQSS----------GT-----TSSTSSSSGGSSG 524

  Fly   589 IATTTKSRQQPPSQSHGHAQSNGHLPDIKLSASDKYNSMQKVAVRSKITSSVSDL-ESVQQYSLH 652
            .:|:.::|..|..| |.|: ..||..  ...|.|.:|...:  .|.....::..: :.:||
Zfish   525 TSTSGRARSDPTHQ-HRHS-GGGHFS--AAVAMDCHNLCPQ--ARQAFVPALGWVGDGLQQ---- 579

  Fly   653 RIYGGVGSGSTHHVSSAATRKHLPGTGSGIVGAMSSKYGSSTLAHNHHNVTHHNASTATIATTTH 717
                  .||.||.|..  |..|:|           .....:...|.||                |
Zfish   580 ------ASGETHPVQE--TTFHVP-----------PHQPKALHPHQHH----------------H 609

  Fly   718 HHHHHGGQQQQQSSSGASTM-AMSHSQSTGD 747
            |||||.....|..:.....: :.|||.||.|
Zfish   610 HHHHHPPPHGQGPARPRPRLYSPSHSASTQD 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	163/375 (43%)
		S_TKc	233..529	CDD:214567	148/320 (46%)
dyrk1aa	NP_001074158.1	PKc_DYRK1	151..488	CDD:271128	151/338 (45%)
		S_TKc	164..483	CDD:214567	148/320 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840