DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43333 and YLR001C

DIOPT Version :9

Sequence 1:	NP_788051.1	Gene:	CG43333 / 34830	FlyBaseID:	FBgn0263038	Length:	1166	Species:	Drosophila melanogaster
Sequence 2:	NP_013101.1	Gene:	YLR001C / 850687	SGDID:	S000003991	Length:	862	Species:	Saccharomyces cerevisiae

Alignment Length:	530	Identity:	114/530 - (21%)
Similarity:	191/530 - (36%)	Gaps:	161/530 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   702 LPPSVSRLTLPNDELVEIKSGKIIQTTRAPTTTTSTTTTTTTTPTPFISRGTPSNHRQYHPSRTS 766
            :.|.::.|.:..||  |.:..||.                    :.|||  :.||:..|
Yeast   164 IQPQINELLVQLDE--ETQDLKIF--------------------SDFIS--SFSNYNAY------ 198

  Fly   767 TTTTTTTTTTAPTTA----------------RHNLIFESSTSHVNAASLIRTTTS--------PI 807
               |.::|...|...                ::|.:.:|:|  ::.|......||        .:
Yeast   199 ---TNSSTVLVPLDVNFRKFFNTIEINYLLDKYNKLGKSNT--ISQAKWAADRTSLLQELIIDDV 258

  Fly   808 YGGSTVTVSPYLEGVSTHLPVVTERLSDVANNAELLPPIPQYADALVQETENTEKAAQANPPTSS 872
            |||.              ||  .|.:.:..||.:|.         :...:|.|  :...|....|
Yeast   259 YGGI--------------LP--KELILENKNNRKLF---------MKSNSEGT--SVSVNNSDYS 296

  Fly   873 VLSNPSEDL--------LQILKTNGLFAMAKYLRQ------------SGLDSILNETGPYTIFVP 917
            .:||...::        |..|:|:..|...|||..            ..|:..:......|||||
Yeast   297 PISNRIFEIGVVHGFSDLDFLRTHIQFDAEKYLHGLNCSEFVKELYFRDLEKFIQNGRKITIFVP 361

  Fly   918 TDKAFKNLLVQLGGPERAEEKFQSNPRLLSGLLLHHVIPGAFEIATLQDEMTGVSLAGTQL---- 978
              :|..|           |::..:.|.     ||:|.:.|..::......:..:..|.||:
Yeast   362 --QASFN-----------EDRGYTKPS-----LLYHFVEGKIDLEQDFSSLRPIQYAPTQIYDSA 408

  Fly   979 ---RVNQYNMHDQEWNDVTLTT----INGAMVVLNKKDIKIPQGVAHAVDRVMFPLPVGDILQTL 1036
               ...:...|.|::. :|.:.    |||...:||.|..:|.....:::|..: .|| ||::.:|
Yeast   409 FCSSAKRLGGHCQKFK-ITRSNKGYYINGRFKILNTKPYEIGNTSIYSIDDDL-QLP-GDLVLSL 470

  Fly  1037 QSDREGRFSNFLKILYTSGLSEKLQSKGVKTYTVFAPVDKSFSELDSDTLEKLYNDKDTAEQFAM 1101
            ..  |...|..|.:|....|.: |.|.. |.||:..|...|:...|. |::.|.::| ||....|
Yeast   471 AP--ENHCSISLMLLKELNLLD-LPSNH-KGYTILLPCMNSWDNNDL-TIDYLRSNK-TALNLLM 529

  Fly  1102 KHIV-PGALFSAGMRFYQVK--------DSLSTGKTVI-----LQKTSAGKIKVNDAQMVTSNIP 1152
            :::: ...::|..   |.:.        :|:|.|...|     |.|.|...||.:.....:|:|.
Yeast   530 RNLIFEDLIYSNN---YSISTTVKNLYGNSVSIGVQKIVGSQNLTKISVSTIKESIIIEESSDIF 591

  Fly  1153 ATNGVIHALD 1162
            ...||||.:|
Yeast   592 FNQGVIHPID 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43333	NP_788051.1	FAS1	844..1026	CDD:225214	41/212 (19%)
		Fasciclin	889..1026	CDD:280607	32/159 (20%)
		Fasciclin	1042..1165	CDD:280607	36/135 (27%)
YLR001C	NP_013101.1	Fasciclin	<36..>86	CDD:413430
		Fasciclin	78..468	CDD:413430	76/386 (20%)
		Fasciclin	493..603	CDD:413430	31/115 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10900
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930