DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43333 and Postn

DIOPT Version :9

Sequence 1:	NP_788051.1	Gene:	CG43333 / 34830	FlyBaseID:	FBgn0263038	Length:	1166	Species:	Drosophila melanogaster
Sequence 2:	XP_006232397.1	Gene:	Postn / 361945	RGDID:	1305285	Length:	838	Species:	Rattus norvegicus

Alignment Length:	678	Identity:	142/678 - (20%)
Similarity:	231/678 - (34%)	Gaps:	193/678 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 LGGETKLSLSDVAPSKSKDLELPGGGKVQILRSPDPQESDTLPSG---SLPGGVDLSSLAALYGG 585
            :|..|....|||  ||.:: |:.|.|..... :|..:..|.|.|.   .|...|::..|.||:
  Rat   110 VGATTTQHYSDV--SKLRE-EIEGKGSYTYF-APSNEAWDNLDSDIRRGLENNVNVELLNALH-- 168

  Fly   586 GAGDIQGISNGANSIASSAVITSDSDEPPSLEELAKRGL-IPDGYEIEGL----SPKSQAPATAA 645
                        :.:.:..::|.|          .|.|: ||..|...||    .|........|
  Rat   169 ------------SHMVNKRMLTKD----------LKHGMVIPSMYNNLGLFINHYPNGVVTVNCA 211

  Fly   646 PPTLPPKKKAT----YVYLEEQTDGSFKIQG-VKANGEKETKQTGSEVESILERI-RSGEIKL-- 702
             ..:...:.||    :|.....|.....||. ::|..|..:.:..:....:||.: |.|...|
  Rat   212 -RVIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDELSSFRAAAITSDLLESLGRDGHFTLFA 275

  Fly   703 PPSVSRLTLPNDELVEIKSGKIIQTTRAPTTTTSTTTTTTTTPTPFISRGTPSNHRQYHPSRTST 767
            |.:.:...||...|..|...|:.....                            .:||...|..
  Rat   276 PTNEAFEKLPRGVLERIMGDKVASEAL----------------------------MKYHILNTLQ 312

  Fly   768 TTTTTTTTTAPTTARHNLIFESSTSHVNAASLIRTTTSPIYGGSTVTVSPYLEGVSTHLPVVTER 832
            .:...|         ...:||:..                  |:|:.:....:.:|.:...:..:
  Rat   313 CSEAIT---------GGAVFETME------------------GNTIEIGCEGDSISINGIKMVNK 350

  Fly   833 LSDVANNA------ELLPPIPQYADALV-----QETENTEKAAQANPPTSSVLSNPSEDLLQILK 886
            ...|..|.      |:|  ||..|..::     |:|..|:..||.
  Rat   351 KDIVTKNGVIHLIDEVL--IPDSAKQVIELAGKQQTTFTDLVAQL-------------------- 393

  Fly   887 TNGLFAMAKYLRQSGLDSILNETGPYTIFVPTDKAFKNLLVQLGGPERAEEKFQSNPRLLSGLLL 951
                          ||.|.|...|.||:..|.:.||            :::....:.|||..:|.
  Rat   394 --------------GLASSLKPDGEYTLLAPVNNAF------------SDDTLSMDQRLLKLILQ 432

  Fly   952 HHVIPGAFEIATLQDEMTGVSLAGTQLRVNQYNMHDQEWNDVTLTTINGAMVVLNKKDIKIPQGV 1016
            :|::.....::.|.:.....::.|.||||..|.         |...|..:.:|...|..:  .|.
  Rat   433 NHILKVKVGLSDLYNGQILETIGGKQLRVFVYR---------TAICIENSCMVRGSKQGR--NGA 486

  Fly  1017 AHAVDRVMFPLPVGDILQTLQSDREGRFSNFLKILYTSGLSEKLQSKGVKTYTVFAPVDKSFSEL 1081
            .|....::.|.. ..:.:.|:.|:  |||.||.:|..:.|.:.|...|  .:|:|||.:.:|..:
  Rat   487 IHIFREIIQPAE-KSLHEKLRQDK--RFSIFLSLLEAADLKDLLTQPG--DWTLFAPTNDAFKGM 546

  Fly  1082 DSDTLEKLYNDKDTAEQFAMKHIVPGALFSAGMRFYQVKDSLSTGKTVILQKTSAGKI------- 1139
            .::..|.|..||:..:...:.|:.||.....|         ...|.|.||:.|...||
  Rat   547 TNEEREILIGDKNALQNIILYHLTPGVYIGKG---------FEPGVTNILKTTQGSKIYVKGVNE 602

  Fly  1140 --KVNDAQMVTSNIPATNGVIHALDGVL 1165
              .||:.:...|:|..||||||.:|.:|
  Rat   603 TLLVNELKSKESDIMTTNGVIHVVDKLL 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43333	NP_788051.1	FAS1	844..1026	CDD:225214	36/186 (19%)
		Fasciclin	889..1026	CDD:280607	28/136 (21%)
		Fasciclin	1042..1165	CDD:280607	40/131 (31%)
Postn	XP_006232397.1	Fasciclin	111..232	CDD:396845	33/149 (22%)
		Fasciclin	247..369	CDD:396845	25/178 (14%)
		Fasciclin	384..496	CDD:396845	32/168 (19%)
		Fasciclin	509..632	CDD:396845	41/135 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10449
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	1	1.100	-	-	O	PTHR10900
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810