DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43333 and Tgfbi

DIOPT Version :9

Sequence 1:	NP_788051.1	Gene:	CG43333 / 34830	FlyBaseID:	FBgn0263038	Length:	1166	Species:	Drosophila melanogaster
Sequence 2:	NP_033395.1	Gene:	Tgfbi / 21810	MGIID:	99959	Length:	683	Species:	Mus musculus

Alignment Length:	766	Identity:	163/766 - (21%)
Similarity:	275/766 - (35%)	Gaps:	199/766 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 LKQLKAALSEAPQQPLTGNKTYDEMDLVL-----------PNGQRVQVIRTTDPNLVQGQKAYSQ 512
            |..|..|||..|...|.| .......|||           ||...||.:..|:.......|.:.|
Mouse     7 LLTLALALSVGPAGTLAG-PAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNKKYFTNCKQWYQ 70

  Fly   513 EQL---QTLLAQQALGGETK----------LSLSD------VAPSKSKDL----------ELPGG 548
            .::   .|:::.:...|..|          |.||:      |..|.:..|          |:.|.
Mouse    71 RKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETMGVVGSTTTQLYTDRTEKLRPEMEGP 135

  Fly   549 GKVQILRSPDPQESDTLPS---GSLPGGVDLSSLAALYGGGAGDIQGISNGANSIASSAVITSDS 610
            |...|. :|..:...:||:   .||...|::..|.||              ...:....|:|
Mouse   136 GSFTIF-APSNEAWSSLPAEVLDSLVSNVNIELLNAL--------------RYHMVDRRVLT--- 182

  Fly   611 DEPPSLEELAKRGLIPDGYEIEGLSPKSQAPATAAPPTLPPKKKATYVYLEEQTDGSFKIQGVKA 675
                  :|| |.|:                       ||....:.:.:.:....:|...:...:.
Mouse   183 ------DEL-KHGM-----------------------TLTSMYQNSNIQIHHYPNGIVTVNCARL 217

  Fly   676 NGEKETKQTGSEVESILERIRSGEIKLPPSVSRLTLPNDELVEIKSGKIIQTTRAPTTTTSTTTT 740
              .|......:.|..:::::          :|.:|....:::||:.  ..:|.||....:...|.
Mouse   218 --LKADHHATNGVVHLIDKV----------ISTITNNIQQIIEIED--TFETLRAAVAASGLNTV 268

  Fly   741 -------TTTTPTPFISRGTPSNHRQYHPSRTSTTTTTTTTTTAPTTAR---HNLIFESSTSHVN 795
                   |...||.......|:.             |.......|...|   :|.|.:|:   :.
Mouse   269 LEGDGQFTLLAPTNEAFEKIPAE-------------TLNRILGDPEALRDLLNNHILKSA---MC 317

  Fly   796 AASLIRTTTSPIYGGSTVTVSPYLEGVSTHLPVVTERLSDVANNA------ELLPPIPQYADALV 854
            |.:::...:....||:|:.|....:.::.:...|......:|.|.      |||  ||..|..|:
Mouse   318 AEAIVAGMSMETLGGTTLEVGCSGDKLTINGKAVISNKDILATNGVIHFIDELL--IPDSAKTLL 380

  Fly   855 QETENTEKAAQANPPTSSVLSNPSEDLLQILKTNGLFAMAKYLRQSGLDSILNETGPYTIFVPTD 919
                  |.|.:::..|:          :.|||            |:|||:.|:.....|...|.:
Mouse   381 ------ELAGESDVSTA----------IDILK------------QAGLDTHLSGKEQLTFLAPLN 417

  Fly   920 KAFKNLLVQLGGPERAEEKFQSNPRLLSGLLLHHVIPGAFEIATLQDEMTGVSLAGTQLRVNQYN 984
            ..||:      |..|.:.:.::       |||:|::........|....|..:|.|.:|||..|.
Mouse   418 SVFKD------GVPRIDAQMKT-------LLLNHMVKEQLASKYLYSGQTLDTLGGKKLRVFVYR 469

  Fly   985 MHDQEWNDVTLTTINGAMVVLNKKDIKIPQGVAHAVDRVMFPLPVGDILQTLQSDREGRFSNFLK 1049
            .        :|...|..:...:|:.   ..|....:||::.| |:|.::..|:.|  .|||..:.
Mouse   470 N--------SLCIENSCIAAHDKRG---RFGTLFTMDRMLTP-PMGTVMDVLKGD--NRFSMLVA 520

  Fly  1050 ILYTSGLSEKLQSKGVKTYTVFAPVDKSFSELDSDTLEKLYNDKDTAEQFAMKHIVPGALFSAGM 1114
            .:.::||.|.|..:||  ||||||.:::|..:..:.|.||..:..........||....|.|.|:
Mouse   521 AIQSAGLMEILNREGV--YTVFAPTNEAFQAMPPEELNKLLANAKELTNILKYHIGDEILVSGGI 583

  Fly  1115 RFYQVKDSLSTGKTVILQKTSAGKIKVNDAQMVTSNIPATNGVIHALDGVL 1165
            .......||...|..:..|.:.  :.||...:..::|.|||||::|::.||
Mouse   584 GALVRLKSLQGDKLEVSSKNNV--VSVNKEPVAETDIMATNGVVYAINTVL 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43333	NP_788051.1	FAS1	844..1026	CDD:225214	39/181 (22%)
		Fasciclin	889..1026	CDD:280607	29/136 (21%)
		Fasciclin	1042..1165	CDD:280607	37/122 (30%)
Tgfbi	NP_033395.1	Fasciclin	133..236	CDD:280607	23/162 (14%)
		Fasciclin	253..373	CDD:280607	25/137 (18%)
		Fasciclin	386..500	CDD:280607	33/159 (21%)
		Fasciclin	514..634	CDD:280607	39/123 (32%)
		Cell attachment site. /evidence=ECO:0000255	642..644
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	0.196	Domainoid score	I11151
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	1	1.100	-	-	O	PTHR10900
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.770