DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43333 and Tgfbi

DIOPT Version :9

Sequence 1:	NP_788051.1	Gene:	CG43333 / 34830	FlyBaseID:	FBgn0263038	Length:	1166	Species:	Drosophila melanogaster
Sequence 2:	NP_446254.1	Gene:	Tgfbi / 116487	RGDID:	620017	Length:	685	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	106/472 - (22%)
Similarity:	188/472 - (39%)	Gaps:	87/472 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 VSRLTLPNDELVEIKSGKIIQTTRAPTTTTSTTTT-------TTTTPTPFISRGTPSNHRQYHPS 763
            :|.:|....:::||:.  ..:|.||....:...|.       |...||.......|:.
  Rat   236 ISTVTNNIQQIIEIED--TFETLRAAVAASGLNTVLEGDGQFTLLAPTNEAFEKIPAE------- 291

  Fly   764 RTSTTTTTTTTTTAPTTAR---HNLIFESSTSHVNAASLIRTTTSPIYGGSTVTVSPYLEGVSTH 825
                  |.......|...|   :|.|.:::   :.|.:::........||:|:.|     |.|..
  Rat   292 ------TLNRILGDPEALRDLLNNHILKTA---MCAEAIVAGMAMETLGGTTLEV-----GCSGD 342

  Fly   826 LPVVTERLSDVANNAELLPP--IPQYADALVQETENTEKAAQANPPTSSVLSNPSEDLLQILKTN 888
            :..:..:.  |.:|.::|..  :..:.|.|                   ::.:.::.||::...:
  Rat   343 MLTINGKA--VISNKDILATNGVIHFIDEL-------------------LIPDSAKTLLELASES 386

  Fly   889 GLFAMAKYLRQSGLDSILNETGPYTIFVPTDKAFKNLLVQLGGPERAEEKFQSNPRLLSGLLLHH 953
            .:......|||:||.:.|:.....|...|.:..||:.:.::.|.             :..|||:|
  Rat   387 DVSTAIDLLRQAGLSTHLSGKEQLTFLAPLNSVFKDGVPRIDGQ-------------MKTLLLNH 438

  Fly   954 VIPGAFEIATLQDEMTGVSLAGTQLRVNQYNMHDQEWNDVTLTTINGAMVVLNKKDIKIPQGVAH 1018
            ::.|......|....|..:|.|.:|||..|..        :|...|..:...:||.   ..|...
  Rat   439 MVKGQLASKYLYSGQTLDTLGGKKLRVFVYRN--------SLCIENSCIAAHDKKG---RYGTLF 492

  Fly  1019 AVDRVMFPLPVGDILQTLQSDREGRFSNFLKILYTSGLSEKLQSKGVKTYTVFAPVDKSFSELDS 1083
            .:||::.| |:|.::..|:.|  .|||..:..:.::||.|.|..:||  ||||||.:::|..:..
  Rat   493 TMDRMLTP-PMGTVMDVLKGD--NRFSMLVAAIQSAGLMETLNREGV--YTVFAPTNEAFQAMPP 552

  Fly  1084 DTLEKLYNDKDTAEQFAMKHIVPGALFSAGMRFYQVKDSLSTGKTVILQKTSAGKIKVNDAQMVT 1148
            :.|.||..:..........||....|.|.|:.......||...|..:..|.:.  :.||...:..
  Rat   553 EELNKLLANAKELTNILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSSKNNV--VSVNKEPVAE 615

  Fly  1149 SNIPATNGVIHALDGVL 1165
            ::|.|||||::|::.||
  Rat   616 TDIMATNGVVYAINTVL 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43333	NP_788051.1	FAS1	844..1026	CDD:225214	35/183 (19%)
		Fasciclin	889..1026	CDD:280607	31/136 (23%)
		Fasciclin	1042..1165	CDD:280607	37/122 (30%)
Tgfbi	NP_446254.1	Fasciclin	133..236	CDD:280607	106/472 (22%)
		Fasciclin	253..373	CDD:280607	25/161 (16%)
		Fasciclin	386..500	CDD:280607	31/137 (23%)
		Fasciclin	514..634	CDD:280607	39/123 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I10929
eggNOG	1	0.900	-	-		E1_COG2335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D926852at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100594
Panther	1	1.100	-	-	O	PTHR10900
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780