DRSC/TRiP Functional Genomics Resources

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Protein Alignment IGFALS and CG7896

DIOPT Version :9

Sequence 1:NP_001139478.1 Gene:IGFALS / 3483 HGNCID:5468 Length:643 Species:Homo sapiens
Sequence 2:NP_651754.1 Gene:CG7896 / 43552 FlyBaseID:FBgn0039728 Length:1392 Species:Drosophila melanogaster


Alignment Length:602 Identity:179/602 - (29%)
Similarity:262/602 - (43%) Gaps:86/602 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    26 AHSGRALLG--PPPQASPPAGGLALALLLLSWVALGPRSLEGAD-PGTPGEAEGPACP-AACVCS 86
            ||.|..:|.  |.|:.| ||..|.....::.:.|.|.......| .......:.|..| .|.:.:
  Fly    22 AHLGHPILAWRPCPELS-PALRLPCRCNVVPFAATGQLGAVAMDCDRVVFHGDAPQLPYGAPIVA 85

Human    87 YDD------------------DADELSVFCSSRNL-TRLP----DGVPGGTQALWLD----GNNL 124
            |..                  ..:||.:   |.|| .|:|    ||:......|.|.    |:||
  Fly    86 YTQRHSGQQVLPAQTFGQLKLTIEELDL---SYNLIRRIPEKAFDGLKDSLNELRLANNLLGDNL 147

Human   125 SSV-PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALAS 188
            :.: ..|....|.:|..|:|.|.::..:|...|.|..:|...:::||.|.|:...:.....||..
  Fly   148 NPIFSTAELHVLKNLRLLDLSGNKIKLIEEGLLKGCMDLKEFYIDRNSLTSVPTNSLNGPSALRH 212

Human   189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFS 253
            |.|..|::..|....|.....|..::|..|.:..:...||:||..:||:.|||||:::|...:|.
  Fly   213 LSLRQNQIGSLLADSFNAQRQLEIIDLRHNVIRSIDSLAFKGLQKIREIKLAGNRISHLNSDVFE 277

Human   254 GLAELRELDLSRN--------ALRAI--------KANVFVQLP--------RLQKLYLDRNLIAA 294
            .|..|::||||.|        ||.|:        .:|:..||.        .|:.|.:.||.|..
  Fly   278 KLQSLQKLDLSENFFGQFPTVALAAVPGLKHLNLSSNMLQQLDYTHMQVVRSLESLDISRNTITT 342

Human   295 VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQL 359
            :.||.|..:.||::||||.|.:..:.:|...||..|:.|.:..|.|..:.......|..|..|||
  Fly   343 ITPGTFREMGALKYLDLSLNSLRTIEDDALEGLDSLQTLIIKDNNILLVPGSALGRLPQLTSLQL 407

Human   360 GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 424
            .:||:..|   |.|.||.|:             ||      ::..::||.|.:|.||...|:...
  Fly   408 DYNRVAAL---SAEILGSLQ-------------AG------DITTLSLSRNVIRELPPGSFQMFS 450

Human   425 KLHSLHLEGSCLGRIRPHTFTGL-SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLP 488
            .||:|.|.|:.|..|...||.|| |.|..|.|..|.|.|: ..:.|.|.||..|||:.|.||.||
  Fly   451 SLHTLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGL-GGAPWVLPELRSLDLSGNTLTELP 514

Human   489 HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRN 553
            ..:|:.|..::.|.||.|.|..|......||.|...:|:|...:..:...|||.|..|:::.|.:
  Fly   515 STIFEELENVQSLNLSGNHLTPLTGALFKPLDRLQVIDLSGCNIRQISGDLLAGLQDLKHIYLND 579

Human   554 NSLRTFTPQPPGLERLW 570
            |.|:..  |......||
  Fly   580 NQLQEL--QDGSFVNLW 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGFALSNP_001139478.1 LRRNT 78..116 CDD:214470 12/61 (20%)
leucine-rich repeat 95..113 CDD:275380 7/22 (32%)
leucine-rich repeat 114..137 CDD:275380 7/27 (26%)
leucine-rich repeat 138..161 CDD:275380 7/22 (32%)
LRR_8 141..196 CDD:290566 16/54 (30%)
leucine-rich repeat 162..185 CDD:275380 5/22 (23%)
LRR_8 184..244 CDD:290566 20/59 (34%)
leucine-rich repeat 186..209 CDD:275380 6/22 (27%)
leucine-rich repeat 210..233 CDD:275380 7/22 (32%)
leucine-rich repeat 234..257 CDD:275380 10/22 (45%)
LRR_8 257..316 CDD:290566 27/82 (33%)
leucine-rich repeat 258..281 CDD:275380 12/46 (26%)
leucine-rich repeat 282..305 CDD:275380 8/22 (36%)
leucine-rich repeat 306..324 CDD:275380 7/17 (41%)
LRR_8 336..388 CDD:290566 15/51 (29%)
leucine-rich repeat 354..377 CDD:275380 10/22 (45%)
LRR_8 377..433 CDD:290566 14/55 (25%)
leucine-rich repeat 378..401 CDD:275380 3/22 (14%)
leucine-rich repeat 402..423 CDD:275380 7/20 (35%)
LRR_8 425..484 CDD:290566 26/59 (44%)
leucine-rich repeat 426..447 CDD:275380 9/20 (45%)
leucine-rich repeat 450..473 CDD:275380 8/22 (36%)
leucine-rich repeat 474..497 CDD:275380 11/22 (50%)
LRR_8 476..532 CDD:290566 21/55 (38%)
leucine-rich repeat 498..519 CDD:275380 6/20 (30%)
leucine-rich repeat 522..543 CDD:275380 5/20 (25%)
LRR_8 524..575 CDD:290566 13/47 (28%)
leucine-rich repeat 546..565 CDD:275380 5/18 (28%)
TPKR_C2 574..618 CDD:301599
CG7896NP_651754.1 LRR_8 109..172 CDD:290566 20/65 (31%)
leucine-rich repeat 109..132 CDD:275380 9/25 (36%)
LRR_RI <132..338 CDD:238064 57/205 (28%)
leucine-rich repeat 133..161 CDD:275380 7/27 (26%)
LRR_8 160..220 CDD:290566 17/59 (29%)
leucine-rich repeat 162..185 CDD:275380 7/22 (32%)
leucine-rich repeat 186..209 CDD:275380 5/22 (23%)
leucine-rich repeat 210..233 CDD:275380 6/22 (27%)
LRR_8 232..290 CDD:290566 22/57 (39%)
leucine-rich repeat 234..257 CDD:275380 7/22 (32%)
leucine-rich repeat 258..281 CDD:275380 10/22 (45%)
LRR_RI 273..535 CDD:238064 94/284 (33%)
LRR_8 281..338 CDD:290566 14/56 (25%)
leucine-rich repeat 282..329 CDD:275380 12/46 (26%)
LRR_8 328..388 CDD:290566 21/59 (36%)
leucine-rich repeat 330..353 CDD:275380 8/22 (36%)
leucine-rich repeat 354..377 CDD:275380 9/22 (41%)
leucine-rich repeat 378..401 CDD:275380 5/22 (23%)
leucine-rich repeat 402..425 CDD:275380 12/38 (32%)
leucine-rich repeat 428..451 CDD:275380 7/22 (32%)
LRR_8 429..487 CDD:290566 23/57 (40%)
leucine-rich repeat 452..473 CDD:275380 9/20 (45%)
leucine-rich repeat 477..497 CDD:275378 7/20 (35%)
LRR_8 498..558 CDD:290566 23/59 (39%)
leucine-rich repeat 500..523 CDD:275380 11/22 (50%)
LRR_RI 502..769 CDD:238064 32/95 (34%)
leucine-rich repeat 524..547 CDD:275380 8/22 (36%)
leucine-rich repeat 548..571 CDD:275380 6/22 (27%)
LRR_8 572..630 CDD:290566 7/25 (28%)
leucine-rich repeat 572..595 CDD:275380 7/25 (28%)
leucine-rich repeat 596..619 CDD:275380
LRR_8 619..678 CDD:290566
leucine-rich repeat 620..643 CDD:275380
leucine-rich repeat 644..667 CDD:275380
LRR_8 666..726 CDD:290566
leucine-rich repeat 668..691 CDD:275380
leucine-rich repeat 692..715 CDD:275380
LRR_8 714..774 CDD:290566
leucine-rich repeat 716..739 CDD:275380
leucine-rich repeat 740..761 CDD:275380
leucine-rich repeat 764..789 CDD:275380
leucine-rich repeat 790..810 CDD:275380
leucine-rich repeat 818..850 CDD:275380
leucine-rich repeat 863..883 CDD:275378
LRR_RI <878..1070 CDD:238064
LRR_8 884..944 CDD:290566
LRR_4 884..925 CDD:289563
leucine-rich repeat 884..907 CDD:275380
leucine-rich repeat 908..933 CDD:275380
leucine-rich repeat 934..955 CDD:275380
leucine-rich repeat 958..982 CDD:275380
leucine-rich repeat 983..1055 CDD:275380
leucine-rich repeat 1009..1033 CDD:275380
leucine-rich repeat 1058..1085 CDD:275380
TPKR_C2 1121..1168 CDD:301599
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40882
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4879
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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