DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IGFALS and Toll-7

DIOPT Version :9

Sequence 1:NP_001139478.1 Gene:IGFALS / 3483 HGNCID:5468 Length:643 Species:Homo sapiens
Sequence 2:NP_523797.1 Gene:Toll-7 / 37272 FlyBaseID:FBgn0034476 Length:1446 Species:Drosophila melanogaster


Alignment Length:808 Identity:207/808 - (25%)
Similarity:298/808 - (36%) Gaps:239/808 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    47 ALALLLL--SW-----VALGPRSLE-------GAD--------------------------PGTP 71
            |:.||||  ||     .||.|:..|       ||.                          |..|
  Fly     3 AILLLLLGFSWSLAVESALAPKESESSASAMLGAGTGAAATVSLSGDYSSLLSNVPAASPVPANP 67

Human    72 GEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLP----DGVPGGTQ----------------- 115
            .:..|||  ..|..||:..:   ||.|:.|.:.|.|    .|..|.:|                 
  Fly    68 SQPSGPA--NQCSWSYNGTS---SVHCALRLIERQPGLDLQGADGSSQLTIQCSELYLFESTLPV 127

Human   116 ----------ALWLDGNNLSSVPPAAFQNLSSLGFL-----NLQGGQLGSLE--PQALLGLENLC 163
                      ||.||...|..:|..||:.|::|..|     |.:.|...:||  |.:|.||:.|.
  Fly   128 AVFARLQTLEALRLDSCKLLQLPNNAFEGLATLKSLRLSTHNSEWGPTRTLELFPDSLGGLKQLT 192

Human   164 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNS------LAV 222
            .|.|..|.||.|..|.......|..|.|:.||:...|...|.      |:|.|..|      |.|
  Fly   193 DLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRIRTAEQMGFA------DMNCGAGSGSAGSELQV 251

Human   223 LPDAAFRGLGSLRE------------LVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANV 275
            | ||:...|.|:.|            |.||.|.|:.|.....:|||.||.::||.|.|..:...:
  Fly   252 L-DASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGL 315

Human   276 FVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED--TFPGLLGLRVLRLSHN 338
            |.....|::::|.:|.:..:..|.|..|:.|..:|||.|::.....|  ||.||:.|.||.|:||
  Fly   316 FAGSKELREIHLQQNELYELPKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHN 380

Human   339 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403
            |:..:..||||:|:||:.|.|.:|.|..:.:.:|..|..|..|.|..|:|..:....|.||..::
  Fly   381 ALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLS 445

Human   404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 468
            .:.|:.|.:..:...||:....|..|.|..:.|..: |.....|:.||.|.|.:|.:...:.||.
  Fly   446 KLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEV-PRALQDLAMLRTLDLGENQIRTFDNQSF 509

Human   469 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP--------LQRAF-- 523
            ..|.:|..|.|..||:.::...:||.|.:|..|.|::||:..:...:...        |.|.|  
  Fly   510 KNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLA 574

Human   524 -----------------------------------WLDVSHNRLEALPN---------------- 537
                                               |||:..|.:|||.|                
  Fly   575 DINGVFATLVSLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVKTLDAS 639

Human   538 ----SLLAPL---GRLRYLSLRNNSLRTFTPQ--------------------------------- 562
                :.:.|:   ..:..|.:.||.:....|.                                 
  Fly   640 HNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFVDKANLARVDLYANQLSKLQLQQLRVAPVVA 704

Human   563 PPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEV 627
            |..|...:|.|||::|.|.:..|:..........||.:...              ||.|.. |..
  Fly   705 PKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHPRVMDMA--------------NIECVM-PHA 754

Human   628 VGLDLRDLS-----------EAH-FAPC 643
            .|..:|.||           |:| ||.|
  Fly   755 RGAAVRPLSGLRPQDFLCRYESHCFALC 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGFALSNP_001139478.1 LRRNT 78..116 CDD:214470 13/68 (19%)
leucine-rich repeat 95..113 CDD:275380 7/21 (33%)
leucine-rich repeat 114..137 CDD:275380 10/49 (20%)
leucine-rich repeat 138..161 CDD:275380 10/29 (34%)
LRR_8 141..196 CDD:290566 21/61 (34%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 184..244 CDD:290566 23/77 (30%)
leucine-rich repeat 186..209 CDD:275380 7/22 (32%)
leucine-rich repeat 210..233 CDD:275380 10/28 (36%)
leucine-rich repeat 234..257 CDD:275380 9/34 (26%)
LRR_8 257..316 CDD:290566 18/58 (31%)
leucine-rich repeat 258..281 CDD:275380 7/22 (32%)
leucine-rich repeat 282..305 CDD:275380 6/22 (27%)
leucine-rich repeat 306..324 CDD:275380 6/19 (32%)
LRR_8 336..388 CDD:290566 20/51 (39%)
leucine-rich repeat 354..377 CDD:275380 7/22 (32%)
LRR_8 377..433 CDD:290566 15/55 (27%)
leucine-rich repeat 378..401 CDD:275380 8/22 (36%)
leucine-rich repeat 402..423 CDD:275380 4/20 (20%)
LRR_8 425..484 CDD:290566 18/58 (31%)
leucine-rich repeat 426..447 CDD:275380 5/20 (25%)
leucine-rich repeat 450..473 CDD:275380 8/22 (36%)
leucine-rich repeat 474..497 CDD:275380 8/22 (36%)
LRR_8 476..532 CDD:290566 19/100 (19%)
leucine-rich repeat 498..519 CDD:275380 5/28 (18%)
leucine-rich repeat 522..543 CDD:275380 9/77 (12%)
LRR_8 524..575 CDD:290566 17/106 (16%)
leucine-rich repeat 546..565 CDD:275380 5/51 (10%)
TPKR_C2 574..618 CDD:301599 7/43 (16%)
Toll-7NP_523797.1 LRR_8 135..201 CDD:290566 23/65 (35%)
leucine-rich repeat 136..159 CDD:275380 9/22 (41%)
leucine-rich repeat 160..190 CDD:275380 10/29 (34%)
LRR_8 189..259 CDD:290566 24/76 (32%)
leucine-rich repeat 191..214 CDD:275380 8/22 (36%)
leucine-rich repeat 215..248 CDD:275380 11/38 (29%)
LRR_RI 247..501 CDD:238064 83/255 (33%)
LRR_8 247..308 CDD:290566 22/61 (36%)
leucine-rich repeat 249..273 CDD:275380 8/24 (33%)
leucine-rich repeat 274..297 CDD:275380 8/22 (36%)
LRR_8 297..356 CDD:290566 18/58 (31%)
leucine-rich repeat 298..321 CDD:275380 7/22 (32%)
leucine-rich repeat 322..345 CDD:275380 6/22 (27%)
LRR_8 345..406 CDD:290566 27/60 (45%)
leucine-rich repeat 346..371 CDD:275380 10/24 (42%)
leucine-rich repeat 372..395 CDD:275380 12/22 (55%)
leucine-rich repeat 396..419 CDD:275380 7/22 (32%)
LRR_8 419..478 CDD:290566 15/58 (26%)
leucine-rich repeat 420..443 CDD:275380 8/22 (36%)
leucine-rich repeat 444..467 CDD:275380 4/22 (18%)
LRR_RI 466..622 CDD:238064 36/156 (23%)
leucine-rich repeat 468..488 CDD:275380 5/20 (25%)
LRR_8 491..549 CDD:290566 20/57 (35%)
leucine-rich repeat 491..514 CDD:275380 8/22 (36%)
leucine-rich repeat 515..536 CDD:275380 7/20 (35%)
leucine-rich repeat 539..562 CDD:275380 5/22 (23%)
leucine-rich repeat 563..585 CDD:275380 3/21 (14%)
leucine-rich repeat 586..626 CDD:275380 8/39 (21%)
leucine-rich repeat 627..653 CDD:275380 1/25 (4%)
LRRCT 716..772 CDD:214507 15/70 (21%)
LRRNT 796..830 CDD:214470
leucine-rich repeat 812..829 CDD:275380
leucine-rich repeat 833..854 CDD:275380
LRR_8 853..913 CDD:290566
leucine-rich repeat 855..878 CDD:275380
LRR_4 878..918 CDD:289563
leucine-rich repeat 879..902 CDD:275380
leucine-rich repeat 903..926 CDD:275380
leucine-rich repeat 927..953 CDD:275380
TIR 1098..1235 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24373
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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