DRSC/TRiP Functional Genomics Resources

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Protein Alignment IGFALS and CG18095

DIOPT Version :9

Sequence 1:NP_001139478.1 Gene:IGFALS / 3483 HGNCID:5468 Length:643 Species:Homo sapiens
Sequence 2:NP_001188805.1 Gene:CG18095 / 34823 FlyBaseID:FBgn0028872 Length:564 Species:Drosophila melanogaster


Alignment Length:505 Identity:146/505 - (28%)
Similarity:209/505 - (41%) Gaps:112/505 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   183 TPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 247
            |..|.||.|||..|..:|:|.|.....|..|.|..:.|:.|.|.:..||..|:.|.|:.|.|:.|
  Fly    38 TELLTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSL 102

Human   248 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLS 312
            :......|..|..||||.|.|..:....|.|.|:||:                        |||.
  Fly   103 RSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQ------------------------LDLR 143

Human   313 HNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQ 377
            :||::.:..|:|.||..|:.|.|:.|.:|.:....|:.||.|..|.|.||||..:...|||....
  Fly   144 YNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTH 208

Human   378 LEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPH 442
            |..|.||.|.|..::..:..||..:..:|||.|.|:.|...||....:|..|.|..:.:.::...
  Fly   209 LRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKE 273

Human   443 TFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNR 507
            ..:||..|.||.:..|.:..|.::||..|..||:||::.|.||.||..||....:||.::|:.|:
  Fly   274 ALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNK 338

Human   508 LAELPA-------------------------DALGPLQRAF--WLDVSHNRLEALPNSLLAPLGR 545
            :.|:.:                         |.|.|....|  ::|:|.|||::|.   |:.|..
  Fly   339 IEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSLN---LSSLLH 400

Human   546 LRYLSLRNNSLRTFTPQPPGLERLWLEGN-------------PW----------------DC--- 578
            .||::|.:|:...          .||..|             ||                ||   
  Fly   401 FRYINLADNNWSC----------NWLVANLVQKLPNSVNFARPWTVINNLSENTTNVEGIDCIEG 455

Human   579 GCPLKALRDFALQNPSAVPRFVQAICEGDDC---------QPPAYTYNNI 619
            |    ..|...|.:.|.||   |...:..||         .||..|:..|
  Fly   456 G----TNRSIILLDVSGVP---QPKSDNCDCVVAYDETNPSPPPLTWPKI 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IGFALSNP_001139478.1 LRRNT 78..116 CDD:214470
leucine-rich repeat 95..113 CDD:275380
leucine-rich repeat 114..137 CDD:275380
leucine-rich repeat 138..161 CDD:275380
LRR_8 141..196 CDD:290566 7/12 (58%)
leucine-rich repeat 162..185 CDD:275380 1/1 (100%)
LRR_8 184..244 CDD:290566 22/59 (37%)
leucine-rich repeat 186..209 CDD:275380 10/22 (45%)
leucine-rich repeat 210..233 CDD:275380 8/22 (36%)
leucine-rich repeat 234..257 CDD:275380 7/22 (32%)
LRR_8 257..316 CDD:290566 16/58 (28%)
leucine-rich repeat 258..281 CDD:275380 9/22 (41%)
leucine-rich repeat 282..305 CDD:275380 2/22 (9%)
leucine-rich repeat 306..324 CDD:275380 6/17 (35%)
LRR_8 336..388 CDD:290566 20/51 (39%)
leucine-rich repeat 354..377 CDD:275380 10/22 (45%)
LRR_8 377..433 CDD:290566 19/55 (35%)
leucine-rich repeat 378..401 CDD:275380 8/22 (36%)
leucine-rich repeat 402..423 CDD:275380 8/20 (40%)
LRR_8 425..484 CDD:290566 18/58 (31%)
leucine-rich repeat 426..447 CDD:275380 3/20 (15%)
leucine-rich repeat 450..473 CDD:275380 8/22 (36%)
leucine-rich repeat 474..497 CDD:275380 11/22 (50%)
LRR_8 476..532 CDD:290566 21/82 (26%)
leucine-rich repeat 498..519 CDD:275380 7/45 (16%)
leucine-rich repeat 522..543 CDD:275380 8/22 (36%)
LRR_8 524..575 CDD:290566 15/63 (24%)
leucine-rich repeat 546..565 CDD:275380 4/18 (22%)
TPKR_C2 574..618 CDD:301599 17/84 (20%)
CG18095NP_001188805.1 leucine-rich repeat 41..64 CDD:275380 10/22 (45%)
LRR_8 64..123 CDD:290566 21/58 (36%)
leucine-rich repeat 65..88 CDD:275380 8/22 (36%)
leucine-rich repeat 89..112 CDD:275380 7/22 (32%)
leucine-rich repeat 113..136 CDD:275380 9/22 (41%)
LRR_RI 115..384 CDD:238064 87/292 (30%)
LRR_8 135..195 CDD:290566 25/83 (30%)
leucine-rich repeat 137..160 CDD:275380 11/46 (24%)
leucine-rich repeat 161..184 CDD:275380 7/22 (32%)
LRR_8 184..243 CDD:290566 22/58 (38%)
leucine-rich repeat 185..208 CDD:275380 10/22 (45%)
leucine-rich repeat 209..232 CDD:275380 8/22 (36%)
LRR_8 232..289 CDD:290566 16/56 (29%)
leucine-rich repeat 233..256 CDD:275380 8/22 (36%)
leucine-rich repeat 257..280 CDD:275380 5/22 (23%)
LRR_8 280..339 CDD:290566 23/58 (40%)
leucine-rich repeat 281..304 CDD:275380 8/22 (36%)
leucine-rich repeat 305..328 CDD:275380 11/22 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BF9C
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
32.770

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