Protein Alignment nAChRalpha5 and HTR3B

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_006019.1
• Gene: HTR3B / 9177
• HGNCID: 5298
• Length: 441
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 114/494 - (23%)
• Similarity: 205/494 - (41%)
• Gaps: 109/494 - (22%)

  Fly   311 YHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLR 375
            ||   |...||..|:...|||.|.:....:...|.:..|:|||.:||:|.|:||.:..|||..|.
Human    33 YH---LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94

  Fly   376 WNTSDYGGVKDLRIPPHRIWKPDVLMYNSAD-EGF-DGTYQTNVVVRNNGSCLYVPPGIFKSTCK 438
            ||:|.:..::::.:|...||.||:::....| |.: |..|   |.|.::|:.....|....|.|.
Human    95 WNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY---VYVNSSGTIENYKPIQVVSACS 156

  Fly   439 IDITWFPFDDQRCEMKFGSWTYDGFQLD---LQLQDETGGDISSYVLNGEWELLGVPGKRNEIYY 500
            ::...||||.|.|.:.|.|..:....:|   |:..::...|..:::.:.|||||.|....:.:..
Human   157 LETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQS 221

  Fly   501 NCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVF 565
            :.  ..:..|.|.:::||..|.|..:|:||.:.:..:.|..|.|||:...::....::|:..|||
Human   222 SA--GGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVF 284

  Fly   566 LNMVAETMPATSDAVPLLGTYFN-CIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWL 629
            ...::..:|.:..:.||:|.:|. |:.|:|.|...|.:|:...|.......|..      |||
Human   285 RVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP------FLC-- 341

  Fly   630 PWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPM 694
               ||                 .||.::|.       .::.|:.::::..
Human   342 ---LR-----------------GDTDADRP-------RVEPRAQRAVVTE--------------- 364

  Fly   695 TPGGTLPHNPAFYRTVYGQ--GDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITD 757
                         .::||:  ...|::..:.|                          :::.|::
Human   365 -------------SSLYGEHLAQPGTLKEVWS--------------------------QLQSISN 390

  Fly   758 QLRKDDECNDIANDWKFAAMVVDRLC----LIIFTMFTI 792
            .|:..|:.:....:|.......|||.    |.:..::||
Human   391 YLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTI 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	112/492 (23%)
HTR3B	NP_006019.1	LIC	8..435	CDD:273305	114/494 (23%)
		Neur_chan_LBD	33..239	CDD:280998	64/213 (30%)
		Neur_chan_memb	246..>328	CDD:280999	23/81 (28%)
		HA-stretch	381..413		5/57 (9%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910