Protein Alignment nAChRalpha5 and CHRFAM7A

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_647536.1
• Gene: CHRFAM7A / 89832
• HGNCID: 15781
• Length: 412
• Species: Homo sapiens
• Alignment Length: 415
• Identity: 196/415 - (47%)
• Similarity: 263/415 - (63%)
• Gaps: 51/415 - (12%)

  Fly   405 ADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL 469
            |||.||.|:.|||:|.::|.|.|:|||||||:|.||:.|||||.|.|::|||||:|.|:.||||:
Human    28 ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM 92

  Fly   470 QDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLI 534
            |:   .|||.|:.||||:|:|:||||:|.:|.||.|||.|:||.:.:|||||||..||:||||||
Human    93 QE---ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 154

  Fly   535 ASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVV 599
            :::|||.|.||.|||||:|||:|:|||||||:.:|||.||||||:|||:..||...|.:|..|||
Human   155 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVV 219

  Fly   600 STILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPG----RPLILEFPTTPCSDTSSERKH 660
            .|:::|.|||.:.|..:|.:|.|::.|.|..|.|||.|||    || ..:.....||..|.|
Human   220 VTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRP-ACQHKQRRCSLASVE--- 280

  Fly   661 QILSDVELKERSSKSLLANVLDIDDDFRH----NCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGP 721
              :|.|.....|:    .|:|.|  .||.    :|.| ||                  |.|.:
Human   281 --MSAVAPPPASN----GNLLYI--GFRGLDGVHCVP-TP------------------DSGVV-- 316

  Fly   722 IGSTRMPDAVTH-----HTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDR 781
              ..||..:.||     |.......:.:|..||:|:|:|.::.|..||...:.::|||||.||||
Human   317 --CGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDR 379

  Fly   782 LCLIIFTMFTILATIAVLLSAPHII 806
            |||:.|::|||:.||.:|:|||:.:
Human   380 LCLMAFSVFTIICTIGILMSAPNFV 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	193/409 (47%)
CHRFAM7A	NP_647536.1	Neur_chan_LBD	<28..400	CDD:332142	193/409 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	184	1.000	Domainoid score	I3411
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1468
Isobase	1	0.950	-	0	Normalized mean entropy	S3299
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	1	1.000	-	-		FOG0000891
OrthoInspector	1	1.000	-	-		mtm8451
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3025
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810