Protein Alignment nAChRalpha5 and CHRNA6

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_004189.1
• Gene: CHRNA6 / 8973
• HGNCID: 15963
• Length: 494
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 183/509 - (35%)
• Similarity: 282/509 - (55%)
• Gaps: 63/509 - (12%)

  Fly   305 KVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEW 369
            |.|:....|:||.|.|...||...|||.|.|||:.:.|.:.:.|:.:|||.||::.||:||:..|
Human    26 KGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIW 90

  Fly   370 NDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFK 434
            ||..|||:..:|.|::.||:|..:|||||:::||:|...|....:|..:::.||...:.||.|||
Human    91 NDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFK 155

  Fly   435 STCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG--DISSYVLNGEWELLGVPGKRNE 497
            |:|.:|||:||||.|.|.:||||||||..::||.:   .|.  |::.:..|.|||::...|.:::
Human   156 SSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI---IGSKVDMNDFWENSEWEIIDASGYKHD 217

  Fly   498 IYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSL 562
            |.||||.|.|.|||::..|||..::|..||||||:.|:.:.:|.|.||.|.|||::|.:::||||
Human   218 IKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSL 282

  Fly   563 TVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLC 627
            ||||.::.||:|:||..|||:|.|....|..|..|:|.|:.:||.|:|...||.|..|::.|||.
Human   283 TVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLK 347

  Fly   628 WLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRH--- 689
            .||.:         |::.:|......|.|:...:     .|..|.:|..||:    ..:.||
Human   348 LLPQV---------LLMRWPLDKTRGTGSDAVPR-----GLARRPAKGKLAS----HGEPRHLKE 394

  Fly   690 --NCRPMTPGGT----LPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEY--ELG 746
              :|.......|    |.|.|..:                             :..::|:  |:.
Human   395 CFHCHKSNELATSKRRLSHQPLQW-----------------------------VVENSEHSPEVE 430

  Fly   747 LILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            .::..::||.:.::..:|..::.:|||:.||||||:.|.:|.:..:..|..:.|
Human   431 DVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	181/501 (36%)
CHRNA6	NP_004189.1	Neur_chan_LBD	34..484	CDD:332142	180/499 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910