Protein Alignment nAChRalpha5 and Chrna6

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_476532.2
• Gene: Chrna6 / 81721
• RGDID: 69281
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 514
• Identity: 180/514 - (35%)
• Similarity: 284/514 - (55%)
• Gaps: 53/514 - (10%)

  Fly   293 WIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQ 357
            ||...:.....::.|::   |::|.|.|...||...|||.|.|||:.:.|.|.:.|:.:|||.||
  Rat    17 WICGFLAFFKGSRGCVS---EEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQ 78

  Fly   358 LLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNN 422
            ::.||:||:..|.|..|.|:.::|.|::.||:|...|||||:::||:|...|....:|..:::.:
  Rat    79 IMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYD 143

  Fly   423 GSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG--DISSYVLNGE 485
            |...:.||.||||:|.:|||:||||.|.|.:||||||||..::||.:   .|.  |::.:..|.|
  Rat   144 GVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI---IGSKVDMNDFWENSE 205

  Fly   486 WELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGE 550
            ||::...|.:::|.||||.|.|.|||::..|||..::|..||||||:.|:.:.:|.|.||.|.||
  Rat   206 WEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGE 270

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTH 615
            |::|.:::||||||||.::.||:|:||..:||:|.|....|..|..|:|.|:.:||.|:|...||
  Rat   271 KVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATH 335

  Fly   616 EMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELK--ERSSKSLLA 678
            .|.:|::.:||...|.||.|.||       ...|..:|...:.|.......::|  .|....||.
  Rat   336 TMPKWVKTMFLQVFPSILMMRRP-------LDKTKEADGVKDPKTHTKRPAKVKFTHRKEPKLLK 393

  Fly   679 NVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEY 743
            .....     |....:.||..|...||.:                             :..::|:
  Rat   394 ECRHC-----HKSSEIAPGKRLSQQPAQW-----------------------------VAENSEH 424

  Fly   744 --ELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
              ::..::..::|||:.::..:|..::.:|||:.||||||:.|.:|.:..:..|:.:.|
  Rat   425 PPDVEDVIDSVQFITENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	177/494 (36%)
Chrna6	NP_476532.2	LIC	34..483	CDD:455710	176/492 (36%)
		LGIC_ECD	34..240	CDD:475126	91/208 (44%)