DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and Chrna1

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_077811.1	Gene:	Chrna1 / 79557	RGDID:	69277	Length:	457	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	183/513 - (35%)
Similarity:	287/513 - (55%)	Gaps:	83/513 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LLIYLNL-SAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLL 359
            :|:.|.| ||...|...||.||:..|...|:::.|||.:..:.:|::.||.|:|:|:|||.||::
  Rat     6 VLLLLGLCSAGTVLGSEHETRLVAKLFKDYSSVVRPVGDHREIVQVTVGLQLIQLINVDEVNQIV 70

  Fly   360 VTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGS 424
            .|||.||.:|.|.||:||..||||||.:.||..:||:|||::||:||..|.....|.|::...|.
  Rat    71 TTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGH 135

  Fly   425 CLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELL 489
            ..:.||.||||.|:|.:|.||||:|.|.||.|:|||||..:.:..:.:. .|:|:::.:|||.:.
  Rat   136 ITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQ-PDLSNFMESGEWVIK 199

  Fly   490 GVPGKRNEIYYNCCPE-PYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLS 553
            ...|.::.::|:|||. ||:|||:..:::|..||:..|:||||:|.:.:..|.|.||.|||||::
  Rat   200 EARGWKHWVFYSCCPNTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSGEKMT 264

  Fly   554 LGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMS 618
            |.:::||||||||.::.|.:|:||.||||:|.|....|..|.:|::.|::::|.|||:..||.|.
  Rat   265 LSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHIMP 329

  Fly   619 EWIRIVFLCWLPWIL---RMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANV 680
            ||:|.||:..:|.|:   .|.||.|              ..:.|.....|:::.:.|.|
  Rat   330 EWVRKVFIDTIPNIMFFSTMKRPSR--------------DKQEKRIFTEDIDISDISGK------ 374

  Fly   681 LDIDDDFRHNCRPMTPGGTLP-----HNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSS 740
                           ||   |     |:|                          :..|..:||:
  Rat   375 ---------------PG---PPPMGFHSP--------------------------LIKHPEVKSA 395

  Fly   741 TEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAV 798
            .|        .:::|.:.::.|.|.|:.:.:||:.|||:|.:.|.:|.:..::.|:||
  Rat   396 IE--------GVKYIAETMKSDQESNNASEEWKYVAMVMDHILLGVFMLVCLIGTLAV 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	176/495 (36%)
Chrna1	NP_077811.1	LIC	21..447	CDD:273305	177/498 (36%)
		Neur_chan_LBD	24..231	CDD:280998	90/207 (43%)
		Neur_chan_memb	238..446	CDD:280999	83/280 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910