Protein Alignment nAChRalpha5 and chrnb3a

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_957514.1
• Gene: chrnb3a / 794401
• ZFINID: ZDB-GENE-040108-1
• Length: 467
• Species: Danio rerio
• Alignment Length: 506
• Identity: 177/506 - (34%)
• Similarity: 262/506 - (51%)
• Gaps: 82/506 - (16%)

  Fly   313 EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWN 377
            |..||.:|...|....||||:.:|.:.:.|||.:.|::||||||||:.|||||..||.|..||||
Zfish    32 EDTLLRNLFRGYQKWVRPVLHANDTITVRFGLKISQLVDVDEKNQLMTTNVWLWEEWTDYKLRWN 96

  Fly   378 TSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            ..||||:..:|:|...||.||:::|.:||..|:|:..|..:||.||:.::.||..:||.|.:|:|
Zfish    97 PEDYGGITSIRVPSETIWLPDIVLYENADGRFEGSLMTKAIVRFNGTIMWTPPASYKSACTMDVT 161

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPY 507
            :||||.|.|.||||||||||..:||.|.| ...|...:..|||||:|...|:|..........||
Zfish   162 FFPFDRQNCSMKFGSWTYDGTMVDLTLVD-AYVDRKDFFDNGEWEILNATGQRGSRRDGIYSYPY 225

  Fly   508 IDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAET 572
              :|::.|::|..|:|...|||||:.::.:.:|.|.||.|.||||||..::|:||||||.::.|.
Zfish   226 --LTYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEI 288

  Fly   573 MPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT-HEMSEWIRIVFLCWLPWILRMS 636
            :|::|..:||:|.|...||..|..|::.|:.::|.|||::.| |.|:.|::.:||..||.:|.|.
Zfish   289 IPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSATYHPMAPWVKSLFLQRLPRLLCMR 353

  Fly   637 RPGRPLILEFPTTPCSDTSSERKHQILSDVEL---------KERSSKSLLANVLDIDDDFRHNCR 692
              |.....::|                 |:||         |:...||.......:.:|
Zfish   354 --GHTDRYQYP-----------------DIELRSPELKRGMKKGQQKSAGGGRAGVKED------ 393

  Fly   693 PMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITD 757
                     .|.|:...:                  :..||                 .:.:|:.
Zfish   394 ---------ENQAWIALL------------------EKATH-----------------SVHYISR 414

  Fly   758 QLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHIIVS 808
            .:||:....::..||||.|.|:||:.|..|...::|.||.:...|..:..|
Zfish   415 HIRKEHFIREVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFTPALQMFFS 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	175/498 (35%)
chrnb3a	NP_957514.1	LIC	9..459	CDD:455710	175/498 (35%)