Protein Alignment nAChRalpha5 and Htr3a

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_006243083.1
• Gene: Htr3a / 79246
• RGDID: 61818
• Length: 488
• Species: Rattus norvegicus
• Alignment Length: 496
• Identity: 146/496 - (29%)
• Similarity: 233/496 - (46%)
• Gaps: 56/496 - (11%)

  Fly   315 RLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTS 379
            ||...||..|....|||.:...|..:|..:.:..|::||||||:|.|.:|.:..|.|..|:|...
  Rat    41 RLSDHLLANYKKGVRPVRDWRKPTLVSIDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPE 105

  Fly   380 DYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWF 444
            |:..|..|.||...||.||:|:....|.|...:. ..|.|.:.|......|....:.|.:||..|
  Rat   106 DFDNVTKLSIPTDSIWVPDILINEFVDVGKSPSI-PYVYVHHQGEVQNYKPLQLVTACSLDIYNF 169

  Fly   445 PFDDQRCEMKFGSWTYDGFQLDLQL---QDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEP 506
            |||.|.|.:.|.||.:....:::.|   .:|...|.|.::..||||||||..|..|.... ....
  Rat   170 PFDVQNCSLTFTSWLHTIQDINISLWRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIE-TSNS 233

  Fly   507 YIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAE 571
            |.::.|.::||||.|:|..:|::|.:.:..:.::||.|||||||::|..:|:||..:|||.:|::
  Rat   234 YAEMKFYVVIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSD 298

  Fly   572 TMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMS 636
            |:|||:...||:|.||...|.::..|:..||.|:...|:......:.:|:|.:.|..:.|:|.:.
  Rat   299 TLPATAIGTPLIGVYFVVCMALLVISLAETIFIVQLVHKQDLQRPVPDWLRHLVLDRIAWLLCLG 363

  Fly   637 RPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLP 701
            .  :|:....|.|..::.:.:....:|..:    .:..|.:.:..|::...|....|:.|    |
  Rat   364 E--QPMAHRPPATFQANKTDDCSGSLLPAM----GNHCSHVGSPQDLEKTSRSRDSPLPP----P 418

  Fly   702 HNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECN 766
            .             :.|:...|                        :|:|:..|...|.|.||..
  Rat   419 R-------------EASLAVRG------------------------LLQELSSIRHSLEKRDEMR 446

  Fly   767 DIANDWKFAAMVVDRLCLIIFTMFTILA---TIAVLLSAPH 804
            ::|.||.....|:|||...|: :..:||   |:..|.|..|
  Rat   447 EVARDWLRVGYVLDRLLFRIY-LLAVLAYSITLVTLWSIWH 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	144/492 (29%)
Htr3a	XP_006243083.1	LIC	5..482	CDD:273305	143/490 (29%)