Protein Alignment nAChRalpha5 and chrna2a

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001035417.1
• Gene: chrna2a / 678575
• ZFINID: ZDB-GENE-040108-2
• Length: 520
• Species: Danio rerio
• Alignment Length: 556
• Identity: 210/556 - (37%)
• Similarity: 295/556 - (53%)
• Gaps: 91/556 - (16%)

  Fly   284 ILNGLNKHSWIFLLIYLNLSAKVCLAGYH---EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLT 345
            :||.|    |:.:||..::...:.....|   |.:|.|.|...||...|||.|.||.:.:.|||:
Zfish     9 LLNNL----WMLILIADHVQPVLSDGWIHAHAEDKLFHKLFIGYNKWSRPVRNISDVVIVKFGLS 69

  Fly   346 LMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFD 410
            :.|:||||||||::.||||||.||||..||||.|::..|..:|:|...||.||:::||:||..|.
Zfish    70 IAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNPSEFDNVTSIRVPSEMIWVPDIVLYNNADGEFA 134

  Fly   411 GTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGG 475
            .|:.|...:.:.|...:|||.|:||:|.||:|:||||.|.|:|||||||||..::||: |.|...
Zfish   135 VTHMTKAHLFHTGKVSWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE-QIEGTV 198

  Fly   476 DISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALL 540
            |:..|..:|||.::...|..|...|:||.|.|.|||:..||||..|:|..||||||:||:.:.:|
Zfish   199 DLKDYWESGEWAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVL 263

  Fly   541 GFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILIL 605
            .|.||.|.|||::|.:::||||||||.::.|.:|:||..:||:|.|....|..|..|:|.|:.:|
Zfish   264 VFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 328

  Fly   606 NYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKE 670
            |.|||:..||.|..|:..|||..:|..|.|.||                ..|:|.:..:::.
Zfish   329 NVHHRSPSTHSMPRWVHSVFLDHIPRWLFMRRP----------------EPEKKPKKTANLS--- 374

  Fly   671 RSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHT 735
             :|||.......:|...   |:.|..|                     ||...|...|.|.:.|.
Zfish   375 -TSKSWFQQETGVDGLV---CQDMEFG---------------------IGLSTSISSPSATSLHL 414

  Fly   736 CIKSSTE-----YEL-----------------------GLI--------LKEIRFITDQLRKDDE 764
               |.:|     |||                       ||:        |:.:|:|.|.||.:||
Zfish   415 ---SDSEPLLQKYELQHLGHVVNLCQHPAKLGNLVSEPGLLFSPCVLRALEGVRYIADHLRAEDE 476

  Fly   765 CNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            ...:..|||:.|||:||:.|.:|.:..:|.||.:.|
Zfish   477 DFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGLFL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	203/524 (39%)
chrna2a	NP_001035417.1	LIC	9..513	CDD:273305	210/556 (38%)
		Neur_chan_LBD	37..243	CDD:280998	102/206 (50%)
		Neur_chan_memb	250..511	CDD:280999	97/307 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910