Protein Alignment nAChRalpha5 and Chrna9

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_075219.2
• Gene: Chrna9 / 65024
• RGDID: 621534
• Length: 479
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 170/505 - (33%)
• Similarity: 266/505 - (52%)
• Gaps: 66/505 - (13%)

  Fly   310 GYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNL 374
            |.:.::|..||.:.|::..|||.:....|.::..:||.||.|:||:||:|...:|::..|:|..|
  Rat    28 GKYAQKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYL 92

  Fly   375 RWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKI 439
            .|:...|..:..:|||...:|:||:::||.||:.......||||:|.:|...:..|.|.||:|.:
  Rat    93 TWDRDQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVV 157

  Fly   440 DITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCP 504
            |:|:||||.|:|.:.||||||:|.|:|: ......||:|.::.:.|||:.|:|..:|.|.|.||.
  Rat   158 DVTYFPFDSQQCNLTFGSWTYNGNQVDI-FNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCS 221

  Fly   505 EPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMV 569
            |||.|:||.::::||:.:|..||:||||||:.:|.|.|.||..||||:||||||||::|||..||
  Rat   222 EPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMV 286

  Fly   570 AETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWIL- 633
            ||.||| |:.|||:|.|:...|.::.:|...||:::|.|...|:...:..|.::|.|.::..||
  Rat   287 AEIMPA-SENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILF 350

  Fly   634 -----------RMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDF 687
                       |.|:....:...:...|.|:..:.|.         |:.|.|..:..:|..|..:
  Rat   351 VYDVGESCLSPRHSQEPEQVTKVYSKLPESNLKTSRN---------KDLSRKKEVRKLLKNDLGY 406

  Fly   688 RHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEI 752
            :         |.:|.|...|...|                 :|:|                 |.|
  Rat   407 Q---------GGIPQNTDSYCARY-----------------EALT-----------------KNI 428

  Fly   753 RFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSA 802
            .:|...|:.....|...::||..|.|:||..:.||.....:.|:.::..|
  Rat   429 EYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	168/500 (34%)
Chrna9	NP_075219.2	LIC	8..474	CDD:455710	169/499 (34%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	82/206 (40%)
		Cys-loop	155..169	CDD:349823	8/13 (62%)