Protein Alignment nAChRalpha5 and Chrna10

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_006229953.1
• Gene: Chrna10 / 64574
• RGDID: 620142
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 500
• Identity: 172/500 - (34%)
• Similarity: 252/500 - (50%)
• Gaps: 79/500 - (15%)

  Fly   307 CLAGYHEKRLLH----DLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKL 367
            ||..  |.||.|    ||...|.:..|||.:....|.::..:||.||||:||:||:|...:|::.
  Rat    67 CLGA--EGRLAHKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQ 129

  Fly   368 EWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGI 432
            ||.|..|.|:...||.:..:|||...:|:||:::||.||.....:..||||||::|:..:..|.|
  Rat   130 EWTDAYLHWDPKAYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAI 194

  Fly   433 FKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNE 497
            .:|:|::|::.||||.|||.:.|||||:.|.|||::.:. |...::.:|.|.||.:||:|.:|..
  Rat   195 TRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRPRG-TSASLADFVENVEWRVLGMPARRRV 258

  Fly   498 IYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSL 562
            :.|.||.|||.|:||.:::|||...|..||::|||.|:.:|.|.|.||.|||||:|||||:||:|
  Rat   259 LTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLAL 323

  Fly   563 TVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLC 627
            |||..::||:|| .:::|||:|.|:...|.||..|...||||:|.|:...:.|.:..|.|::.|.
  Rat   324 TVFQLILAESMP-PAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLG 387

  Fly   628 WLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCR 692
            .|...|.:...|.         ||..:                                     :
  Rat   388 HLAKGLCVRERGE---------PCGQS-------------------------------------K 406

  Fly   693 PMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITD 757
            |:....:|...||              .|.|....|..:.|...           :|..|..|..
  Rat   407 PLESAPSLQPPPA--------------SPAGPCHEPRCLCHQEA-----------LLHHIASIAS 446

  Fly   758 QLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSA 802
            ..|..........|||..|.|:||..|.||....::.::.||:.|
  Rat   447 TFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLIVLVQA 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	169/492 (34%)
Chrna10	XP_006229953.1	LIC	60..476	CDD:455710	167/483 (35%)
		LGIC_ECD	75..281	CDD:475126	85/206 (41%)