Protein Alignment nAChRalpha5 and Htr3b

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_071525.1
• Gene: Htr3b / 58963
• RGDID: 61820
• Length: 437
• Species: Rattus norvegicus
• Alignment Length: 377
• Identity: 100/377 - (26%)
• Similarity: 174/377 - (46%)
• Gaps: 51/377 - (13%)

  Fly   315 RLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTS 379
            ||...||..|:...|||.|.::...:...|.:..::|||.:||.|.|::|.:..|||..|.||:|
  Rat    30 RLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSMWYREVWNDEFLSWNSS 94

  Fly   380 DYGGVKDLRIPPHRIWKPDVLM--YNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            .:..::::.:|...||.||:::  :...:...|..|   |.|.::|:.....|....|.|.:...
  Rat    95 LFDDIQEISLPLSAIWAPDIIINEFVDVERSPDLPY---VYVNSSGTIRNHKPIQVVSACSLQTY 156

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLD---LQLQDETGGDISSYVLNGEWELLGVPGKRNEIYY--NC 502
            .||||.|.|.:.|.|..:....:|   |:.|::...|..|::.:.||:||.|    ...|:  ..
  Rat   157 AFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDKRSFLNDSEWQLLSV----TSTYHIRQS 217

  Fly   503 CPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLN 567
            ....:..|.|.::|||..|.|..:|:||.:.:..:.|..|.|||:...::.....:|:..|||..
  Rat   218 SAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRV 282

  Fly   568 MVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWI 632
            .:::.:|.::....|:|.:|...|.::..|:..:||::.:.:..
  Rat   283 NMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKFLYEE--------------------- 326

  Fly   633 LRMSRPGRPLIL-----------EFPTTPCS-DTSS--ERKHQILSDVELKE 670
             |.|...|||:.           .:...||: ||.|  .::||:.||. ||:
  Rat   327 -RHSEQERPLMCLRGDSDANESRLYLRAPCAEDTESPVRQEHQVPSDT-LKD 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	100/377 (27%)
Htr3b	NP_071525.1	LIC	30..431	CDD:273305	100/377 (27%)
		Neur_chan_LBD	30..233	CDD:280998	60/209 (29%)
		Neur_chan_memb	242..>313	CDD:280999	17/70 (24%)
		HA-stretch	377..409		100/377 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910