Protein Alignment nAChRalpha5 and Htr3b

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_064670.1
• Gene: Htr3b / 57014
• MGIID: 1861899
• Length: 437
• Species: Mus musculus
• Alignment Length: 377
• Identity: 95/377 - (25%)
• Similarity: 174/377 - (46%)
• Gaps: 51/377 - (13%)

  Fly   315 RLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTS 379
            ||...||..|:...|||.|.::...:...|.:..::|||.:||.|.|:||.:..|||..|.||:|
Mouse    30 RLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDVDVQNQKLKTSVWYREVWNDEFLSWNSS 94

  Fly   380 DYGGVKDLRIPPHRIWKPDVLM--YNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDIT 442
            .:..::::.:|...:|.||:::  :...:...|..|   |.|.::|:.....|....|.|.:...
Mouse    95 LFDEIQEISLPLSALWAPDIIINEFVDVERSPDLPY---VYVNSSGTIRNHKPIQVVSACSLQTY 156

  Fly   443 WFPFDDQRCEMKFGSWTYDGFQLD---LQLQDETGGDISSYVLNGEWELLGVPGKRNEIYY--NC 502
            .||||.|.|.:.|.|..:....:|   |:.:::...|..:::.:.||:||.|    :..|:  ..
Mouse   157 AFPFDIQNCSLTFNSILHTVEDIDLGFLRNREDIENDKRAFMNDSEWQLLSV----SSTYHIRQS 217

  Fly   503 CPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLN 567
            ....:..|.|.::|||..|.|..:|:||.:.:..:.|..|.|||:...::.....:|:..|||..
Mouse   218 SAGDFAQIRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRV 282

  Fly   568 MVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWI 632
            .:::.:|.::...||:|.:|...|.::..|:..:||::.:.:..
Mouse   283 NMSDEVPRSAGCTPLIGVFFTVCMALLVLSLSKSILLIKFLYEE--------------------- 326

  Fly   633 LRMSRPGRPLI--------------LEFPTTPCSDTSSERKHQILSDVELKE 670
             |.|...|||:              |..|....:::...::|::.||. ||:
Mouse   327 -RHSGQERPLMCLQGDSDAEESRLYLGAPRADVTESPVHQEHRVPSDT-LKD 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	95/377 (25%)
Htr3b	NP_064670.1	LIC	30..431	CDD:273305	95/377 (25%)
		Neur_chan_LBD	30..233	CDD:280998	58/209 (28%)
		Neur_chan_memb	242..>313	CDD:280999	18/70 (26%)
		HA-stretch	377..409		95/377 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910