Protein Alignment nAChRalpha5 and chrnb5b

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_073778294.1
• Gene: chrnb5b / 569662
• ZFINID: ZDB-GENE-120809-5
• Length: 487
• Species: Danio rerio
• Alignment Length: 532
• Identity: 192/532 - (36%)
• Similarity: 297/532 - (55%)
• Gaps: 73/532 - (13%)

  Fly   281 STQILNGLNKHSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDP--YNTLERPVLNESDPLQLSFG 343
            :.|:.:||    |   .:.|.::...|  ...|:||::.||.|  ||.|.||.:|:|..:.::..
Zfish     2 AAQMASGL----W---FVALTMATVWC--AEVEERLVNYLLSPDRYNKLIRPAVNKSQQVTIAIQ 57

  Fly   344 LTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEG 408
            ::|.|:|.|:|:.|::.||.||...|||..|.|:..:|.|::.:|:|...||.||:::||:||..
Zfish    58 VSLAQLISVNEREQIMTTNCWLTQVWNDYRLMWDPEEYEGMRKVRLPSQHIWLPDIVLYNNADGT 122

  Fly   409 FDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDL-QLQDE 472
            ::.::.:|.||.|||...::||.|:||.|||::..||||.|.|.:||.|||||..::|| .|.|.
Zfish   123 YEVSFYSNAVVSNNGEVAWLPPAIYKSACKIEVRDFPFDQQNCTLKFRSWTYDHTEIDLILLSDF 187

  Fly   473 TGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEP----YIDITFAIIIRRRTLYYFFNLIIPCVL 533
            ...|  .:..:|||:::.:||::||       :|    |:|||:..||||:.|:|..||||||||
Zfish   188 ASRD--DFKPSGEWDIVSLPGRKNE-------DPNDVTYLDITYDFIIRRKPLFYTINLIIPCVL 243

  Fly   534 IASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSV 598
            |.|:|:|.|.||.|.|||::|.:::||:|||||.::::.:|.||.||||:|.|....|.:|..|:
Zfish   244 ITSLAILVFYLPSDCGEKITLCISVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSI 308

  Fly   599 VSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSS--ERKHQ 661
            |:::.:||.|||:..||.|.:|::..||..||..|.|.|||.           |:...  .||||
Zfish   309 VTSVCVLNVHHRSPSTHSMPKWVKYYFLVRLPAFLFMRRPGE-----------SNKRDRFRRKHQ 362

  Fly   662 --ILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIG-PIG 723
              ..|||.:|..:.::        |..|..|                      :.....|| ..|
Zfish   363 QHSSSDVPVKSEADEA--------DSTFFVN----------------------EDSANHIGWRAG 397

  Fly   724 STRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFT 788
            ..:....:.....:|.|.:.|..  :|.:|:|.|:::.:|:...|..|||:.|||:|||.|.||.
Zfish   398 ELQENSELRKRMAVKCSADMEEA--VKGVRYIADKMKSEDDDEGIIEDWKYVAMVIDRLFLWIFV 460

  Fly   789 MFTILATIAVLL 800
            :..:..||.:.:
Zfish   461 LVCVAGTIGLFM 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	186/500 (37%)
chrnb5b	XP_073778294.1	None