DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and chrna9a

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_021326868.1	Gene:	chrna9a / 568807	ZFINID:	ZDB-GENE-090312-63	Length:	580	Species:	Danio rerio

Alignment Length:	588	Identity:	191/588 - (32%)
Similarity:	298/588 - (50%)	Gaps:	91/588 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 IFLLIYLN--LSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEKN 356
            |||:|:::  |.|.....|...::||:||::.|:...|||.:....|.::..:||.||.|:||:|
Zfish     4 IFLVIHISLLLHAVFSAQGRFAQKLLNDLMEGYSNALRPVEDTDKALNVTLQITLSQIKDMDERN 68

  Fly   357 QLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSAD-EGFDGTYQTNVVVR 420
            |:|.|.:|::..|:|..|.|:..:|.|::.:|||.:.:|:||:::||:|| |...|...||||:|
Zfish    69 QVLTTYLWVRQIWHDAYLSWDKEEYDGLEVIRIPSNLVWRPDIVLYNNADEEDSSGPPDTNVVLR 133

  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGE 485
            .||...:..|.|.||:||:|:::||||.|.|.:.||||||:|.|:|:.:..|: ||:|.:|.|.|
Zfish   134 YNGEITWDSPAITKSSCKVDVSYFPFDSQECNLTFGSWTYNGNQVDIAMGMES-GDLSDFVDNVE 197

  Fly   486 WELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGE 550
            ||..|:|..:|.|.|.||.:||.|||:.::::||:.:|.|||::||.||:.:|.|||.||.||||
Zfish   198 WECHGMPAVKNVIMYGCCSDPYPDITYTVLLKRRSSFYIFNLLLPCFLISFLAPLGFYLPADSGE 262

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTH 615
            |:|||||:||:||||..||||:|| .|::|||:|.|:...|.|:.:|...||.|:|.|...|:..
Zfish   263 KVSLGVTVLLALTVFQLMVAESMP-PSESVPLIGKYYIATMTMITASTSLTIFIMNIHFCGAEAK 326

  Fly   616 EMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANV 680
            .:..|.:::.:.::..|..:...|     |..|||.||.........|:.:|......|....:
Zfish   327 PVPHWAKVLIIDYMSKIFFVYEVG-----ENCTTPESDRGPFFSEDPLASLERDGYFDKGFYED- 385

  Fly   681 LDIDD------------DFRH----------------------NCRPMTPGGTLPHNPAFYRTV- 710
            ..:|:            |.||                      .....:|.....|:|.:...:
Zfish   386 CHLDERIRSQFNGYSHRDHRHGNGYHHKNSSYRQHRHEQQRRTRSSSNSPVRQSSHHPKYTHFIG 450

  Fly   711 ------------------------------YGQG-----------DDGSIGPIGSTRMPDAVTHH 734
                                          |.||           |:|.....|:.......|..
Zfish   451 RDGSEKLPLTSQEKLKDSEISIPEKINGYTYDQGNGYLNGVGYLHDNGYSKTFGADSYNKTTTGT 515

  Fly   735 TCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVL 799
            .|:....:    .:::.|.:|.:..|:.........:||..|.|:||..:.:|.:...|.:|.||
Zfish   516 GCVCGKHQ----KLVRNIEYIANCFREQRGHQAKGAEWKKVAKVMDRFFMWVFFIMVFLMSILVL 576

  Fly   800 LSA 802
            ..|
Zfish   577 AKA 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	183/565 (32%)
chrna9a	XP_021326868.1	Neur_chan_LBD	25..231	CDD:308532	89/206 (43%)
chrna9a	XP_021326868.1	Neur_chan_memb	239..>367	CDD:308533	57/133 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920