DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and chrna3

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_001921314.1	Gene:	chrna3 / 568467	ZFINID:	ZDB-GENE-070822-1	Length:	508	Species:	Danio rerio

Alignment Length:	525	Identity:	202/525 - (38%)
Similarity:	304/525 - (57%)	Gaps:	51/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 LLIYLNLSAKVC--LAGY----HEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDE 354
            |||:.:..:.:|  |:|.    .|.||...:...||...|||.|.|||:.:.|.:::.|::.|||
Zfish     6 LLIFFSSFSPLCFLLSGVCCSEAEHRLFSVIFSSYNQYIRPVENVSDPVVVQFEVSMSQLVKVDE 70

  Fly   355 KNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVV 419
            .||::.||:||:..|||..|||:..|:|||:.:|:|.::|||||:::||:|...|....:|..::
Zfish    71 VNQIMETNLWLRHIWNDYKLRWDPKDFGGVEFIRVPSNKIWKPDIVLYNNAVGDFQVDDKTKALL 135

  Fly   420 RNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNG 484
            |.||...::||.||||:||||:|:||||.|.|.|||||||||..::||.|...| .::..:..:|
Zfish   136 RFNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVLIGST-INLKDFWESG 199

  Fly   485 EWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSG 549
            ||.::..||.:::|.||||.|.|.|||:::.|||..|:|..|:||||:||:.:.:|.|.||.|.|
Zfish   200 EWTIIDAPGYKHDIKYNCCEEIYTDITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPSDCG 264

  Fly   550 EKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT 614
            ||::|.:::||||||||.::.||:|:||..:||:|.|....|..|..|:|.|:.:||.|:|...|
Zfish   265 EKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT 329

  Fly   615 HEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCS--------DTSSERKHQ-ILSDVELKE 670
            |.|..|:|.|||..||.::.|:||.:.  .|.|...||        .||..|..| :|...||.|
Zfish   330 HTMPCWVRRVFLSLLPRVMFMTRPEKD--QEVPAKQCSVHPPVSSKQTSVCRGPQLLLCPTELNE 392

  Fly   671 RSSKSLLANVLDIDDDFRHNC-----RPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDA 730
            .|..:.|..        .|:|     ..||..|               .:||. .|..|:...|.
Zfish   393 ASRTAFLCR--------EHHCWKKHISNMTSEG---------------AEDGG-SPCSSSESLDG 433

  Fly   731 VTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILAT 795
               ..|: |:...::...::.:::|.:.:|..:|..::.:|||:.|||:||:.|.:|.:..||.|
Zfish   434 ---FLCM-SAVSPQVREAIESVKYIAENMRLQNEAKEVQDDWKYVAMVIDRIFLWVFVLVCILGT 494

  Fly   796 IAVLL 800
            ..:.|
Zfish   495 AGLFL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	196/502 (39%)
chrna3	XP_001921314.1	LIC	4..499	CDD:273305	201/523 (38%)
		Neur_chan_LBD	29..235	CDD:280998	96/206 (47%)
		Neur_chan_memb	242..498	CDD:280999	96/285 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910