Protein Alignment nAChRalpha5 and chrna3

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_073785858.1
• Gene: chrna3 / 568467
• ZFINID: ZDB-GENE-070822-1
• Length: 572
• Species: Danio rerio
• Alignment Length: 609
• Identity: 216/609 - (35%)
• Similarity: 329/609 - (54%)
• Gaps: 82/609 - (13%)

  Fly   226 SLQQWQLH-VQQRSVLLFRRIAASTIAFISYLGSFAAQLRSSSS-------------SSSNSSNS 276
            ||....|| .|..:..:|..::.:.....::..:.:..|.||||             |...:.|:
Zfish     3 SLSDQYLHWKQDENSCIFCSLSLTHTYMRTHTHTLSLSLSSSSSPGPPLVCTAALFLSPDCTMNT 67

  Fly   277 GNSSSTQILNGLNKHSWIFLLIYLNLSAKVC--LAGY----HEKRLLHDLLDPYNTLERPVLNES 335
            |                 .|||:.:..:.:|  |:|.    .|.||...:...||...|||.|.|
Zfish    68 G-----------------ALLIFFSSFSPLCFLLSGVCCSEAEHRLFSVIFSSYNQYIRPVENVS 115

  Fly   336 DPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVL 400
            ||:.:.|.:::.|::.|||.||::.||:||:..|||..|||:..|:|||:.:|:|.::|||||::
Zfish   116 DPVVVQFEVSMSQLVKVDEVNQIMETNLWLRHIWNDYKLRWDPKDFGGVEFIRVPSNKIWKPDIV 180

  Fly   401 MYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQL 465
            :||:|...|....:|..::|.||...::||.||||:||||:|:||||.|.|.|||||||||..::
Zfish   181 LYNNAVGDFQVDDKTKALLRFNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKI 245

  Fly   466 DLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIP 530
            ||.|...| .::..:..:|||.::..||.:::|.||||.|.|.|||:::.|||..|:|..|:|||
Zfish   246 DLVLIGST-INLKDFWESGEWTIIDAPGYKHDIKYNCCEEIYTDITYSLYIRRLPLFYTINMIIP 309

  Fly   531 CVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVA 595
            |:||:.:.:|.|.||.|.|||::|.:::||||||||.::.||:|:||..:||:|.|....|..|.
Zfish   310 CLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVT 374

  Fly   596 SSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCS-------- 652
            .|:|.|:.:||.|:|...||.|..|:|.|||..||.::.|:||.:.  .|.|...||
Zfish   375 LSIVITVFVLNVHYRTPKTHTMPCWVRRVFLSLLPRVMFMTRPEKD--QEVPAKQCSVHPPVSSK 437

  Fly   653 DTSSERKHQ-ILSDVELKERSSKSLLANVLDIDDDFRHNC-----RPMTPGGTLPHNPAFYRTVY 711
            .||..|..| :|...||.|.|..:.|..        .|:|     ..||..|
Zfish   438 QTSVCRGPQLLLCPTELNEASRTAFLCR--------EHHCWKKHISNMTSEG------------- 481

  Fly   712 GQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAA 776
              .:||. .|..|:...|.   ..|: |:...::...::.:::|.:.:|..:|..::.:|||:.|
Zfish   482 --AEDGG-SPCSSSESLDG---FLCM-SAVSPQVREAIESVKYIAENMRLQNEAKEVQDDWKYVA 539

  Fly   777 MVVDRLCLIIFTMFTILATIAVLL 800
            ||:||:.|.:|.:..||.|..:.|
Zfish   540 MVIDRIFLWVFVLVCILGTAGLFL 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	196/502 (39%)
chrna3	XP_073785858.1	None