DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and chrna11

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001038562.1	Gene:	chrna11 / 566141	ZFINID:	ZDB-GENE-060503-606	Length:	589	Species:	Danio rerio

Alignment Length:	607	Identity:	251/607 - (41%)
Similarity:	349/607 - (57%)	Gaps:	119/607 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 HSWIFLLIYLNLSAKVCLAGYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQIIDVDEK 355
            ||..|.|..::...:|.:.|.:::.||.:||..||.:||||.|:|.||.:...::|:||:|||||
Zfish     3 HSLAFTLCGISALIQVSVQGPYQRTLLKNLLKDYNRMERPVANDSQPLTVFLSMSLIQIMDVDEK 67

  Fly   356 NQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVR 420
            ||:|.||:||.:.|.|..|:||.|:|.|||:||....::|.||:|:|||||:.||.|:::||||.
Zfish    68 NQVLTTNIWLNMHWYDHYLQWNQSEYPGVKNLRFTTDQVWTPDILLYNSADDKFDSTFKSNVVVN 132

  Fly   421 NNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGE 485
            ::|.|.|:|||||.|||.:|:.|||||.|:||:||||||:||:.||||:.:   .|||.|:.|||
Zfish   133 SSGYCNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQMNE---ADISGYMPNGE 194

  Fly   486 WELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGE 550
            |:|:||||.|||::|:||.|||.|:||.:.||||||||..||:|||||::||.||.|.||.||||
Zfish   195 WDLVGVPGTRNELFYDCCKEPYPDVTFVVTIRRRTLYYALNLLIPCVLLSSMTLLIFLLPADSGE 259

  Fly   551 KLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTH 615
            |:|||:|:|||||||:.:|||.||||||::||:|.||..||.:|..||::|:::|.|||.:.:..
Zfish   260 KISLGITVLLSLTVFMLLVAEIMPATSDSIPLIGQYFASIMIIVGMSVIATVVVLQYHHHDPNGG 324

  Fly   616 EMSEWIRIVFLCWLPWILRMSRPG------RPLIL-------------EFPTTPCSDTSSERKHQ 661
            .|.:|:::|.|.|:.|.|||.|||      ||...             ..|..|.|.::....|.
Zfish   325 NMPKWVQLVLLQWVAWFLRMKRPGESEDPERPPCAPHLRRCSSGSQSGSLPNAPGSASADLHHHH 389

  Fly   662 ILSDV----------------------------------------ELKERSSKSLLANVLDIDDD 686
            |.|.:                                        .|.|.|..:|||      |.
Zfish   390 ISSTLHPLHPQSLLQAAAAAGHTHHLHNQTNSANNNGNLLYIGFSSLDEASPPALLA------DS 448

  Fly   687 FRHNCRPMTPGGTL-----------PHNPAFY-----------------RTVYGQGDDGSIGPIG 723
            .:.|.....|..|:           ||.|:.:                 .||.|.|..
Zfish   449 VQRNSMSGGPRPTVVSPPVVGSSPPPHLPSQFCSPPPPPTPNLEATGCPSTVSGGGGG------- 506

  Fly   724 STRMPDAVTHHTCIKSST----EYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCL 784
                        |..|.|    :.:|..||:|:|::.|:.|..||...:...|||||.|:|||||
Zfish   507 ------------CSCSGTSGGGDPQLQAILEEVRYVADRFRGQDENESVTEQWKFAAAVIDRLCL 559

  Fly   785 IIFTMFTILATIAVLLSAPHII 806
            :.|::|.|:.||::|:|||:.:
Zfish   560 VAFSVFNIICTISILMSAPNFV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	242/579 (42%)
chrna11	NP_001038562.1	LIC	2..577	CDD:273305	248/601 (41%)
		Neur_chan_LBD	25..229	CDD:280998	117/206 (57%)
		Neur_chan_memb	236..573	CDD:280999	118/361 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E1_KOG3646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1280
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6506
orthoMCL	1	0.900	-	-		OOG6_104534
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830