Protein Alignment nAChRalpha5 and chrnb2

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_005169811.1
• Gene: chrnb2 / 561906
• ZFINID: ZDB-GENE-070821-3
• Length: 543
• Species: Danio rerio
• Alignment Length: 547
• Identity: 191/547 - (34%)
• Similarity: 291/547 - (53%)
• Gaps: 91/547 - (16%)

  Fly   309 AGY---HEKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLE 368
            :||   .|:||:..||:|  ||.|.||..|.|:.:.:...::|.|:|.|.|:.|::.|||||..|
Zfish    16 SGYGADTEERLVEHLLNPAHYNKLIRPATNGSEVVTVQLMVSLAQLISVHEREQIMTTNVWLTQE 80

  Fly   369 WNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIF 433
            |.|..|.|:..::.|:|.:|:|...||.|||::||:||..::.::.:|.||..:||..::||.|:
Zfish    81 WQDYRLTWSPEEFDGMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSVFWLPPAIY 145

  Fly   434 KSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISS---YVLNGEWELLGVPGKR 495
            ||.|||::..||||.|.|.:.|.|||||..::||.|:    .|::|   :..:|||:::.:||:|
Zfish   146 KSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDLVLR----ADVASMDDFTPSGEWDIIALPGRR 206

  Fly   496 NEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILL 560
            ||   |.....|:|||:..||||:.|:|..|||||||||.|:|:|.|.||.|.|||::|.:::||
Zfish   207 NE---NPSDPTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLL 268

  Fly   561 SLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVF 625
            :|||||.::::.:|.||..|||:|.|....|.:|..|:|:::.:||.|||:..||.|..|:::||
Zfish   269 ALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMPPWVKLVF 333

  Fly   626 LCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKH--------------------QILSDVELKE 670
            |..||.:|.|.:|              ..||||:.                    .:::.:.|..
Zfish   334 LNKLPALLFMRQP--------------RNSSERQRLRQRRRANEQQEGGRGGLAAGLMAGLGLSG 384

  Fly   671 RSSKSLLAN---------------------------VLDIDDDFRHNCRPMTPGGTLPHNPAFYR 708
            .||.|...|                           ..|..:..|...|....||.   ||.
Zfish   385 SSSGSKENNEACTCYVNRASVKQFGAELGGGGGGGGSTDGLNGIREGGRETREGGA---NPL--- 443

  Fly   709 TVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWK 773
                   .||..|.|..:.|..:|.....::...:|..  :..:|||.:.::.:|:...::.|||
Zfish   444 -------QGSALPRGKQQPPTVLTQALLAQACPGFEEA--VDGVRFIANHMKSEDDDRSVSEDWK 499

  Fly   774 FAAMVVDRLCLIIFTMFTILATIAVLL 800
            :.|||:|||.|.||....:..||.:.|
Zfish   500 YVAMVIDRLFLWIFVFVCVFGTIGMFL 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	189/540 (35%)
chrnb2	XP_005169811.1	LIC	4..526	CDD:273305	190/545 (35%)
		Neur_chan_LBD	23..228	CDD:280998	89/211 (42%)
		Neur_chan_memb	235..525	CDD:280999	96/318 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910