Protein Alignment nAChRalpha5 and chrnb2

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: XP_005169811.1
• Gene: chrnb2 / 561906
• ZFINID: ZDB-GENE-070821-3
• Length: 543
• Species: Danio rerio
• Alignment Length: 547
• Identity: 191/547 - (34%)
• Similarity: 291/547 - (53%)
• Gaps: 91/547 - (16%)

  Fly   309 AGY---HEKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLE 368
            :||   .|:||:..||:|  ||.|.||..|.|:.:.:...::|.|:|.|.|:.|::.|||||..|
Zfish    16 SGYGADTEERLVEHLLNPAHYNKLIRPATNGSEVVTVQLMVSLAQLISVHEREQIMTTNVWLTQE 80

  Fly   369 WNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIF 433
            |.|..|.|:..::.|:|.:|:|...||.|||::||:||..::.::.:|.||..:||..::||.|:
Zfish    81 WQDYRLTWSPEEFDGMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSVFWLPPAIY 145

  Fly   434 KSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISS---YVLNGEWELLGVPGKR 495
            ||.|||::..||||.|.|.:.|.|||||..::||.|:    .|::|   :..:|||:::.:||:|
Zfish   146 KSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDLVLR----ADVASMDDFTPSGEWDIIALPGRR 206

  Fly   496 NEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILL 560
            ||   |.....|:|||:..||||:.|:|..|||||||||.|:|:|.|.||.|.|||::|.:::||
Zfish   207 NE---NPSDPTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLL 268

  Fly   561 SLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVF 625
            :|||||.::::.:|.||..|||:|.|....|.:|..|:|:::.:||.|||:..||.|..|:::||
Zfish   269 ALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMPPWVKLVF 333

  Fly   626 LCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKH--------------------QILSDVELKE 670
            |..||.:|.|.:|              ..||||:.                    .:::.:.|..
Zfish   334 LNKLPALLFMRQP--------------RNSSERQRLRQRRRANEQQEGGRGGLAAGLMAGLGLSG 384

  Fly   671 RSSKSLLAN---------------------------VLDIDDDFRHNCRPMTPGGTLPHNPAFYR 708
            .||.|...|                           ..|..:..|...|....||.   ||.
Zfish   385 SSSGSKENNEACTCYVNRASVKQFGAELGGGGGGGGSTDGLNGIREGGRETREGGA---NPL--- 443

  Fly   709 TVYGQGDDGSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWK 773
                   .||..|.|..:.|..:|.....::...:|..  :..:|||.:.::.:|:...::.|||
Zfish   444 -------QGSALPRGKQQPPTVLTQALLAQACPGFEEA--VDGVRFIANHMKSEDDDRSVSEDWK 499

  Fly   774 FAAMVVDRLCLIIFTMFTILATIAVLL 800
            :.|||:|||.|.||....:..||.:.|
Zfish   500 YVAMVIDRLFLWIFVFVCVFGTIGMFL 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	189/540 (35%)
chrnb2	XP_005169811.1	LIC	4..526	CDD:455710	190/545 (35%)
		LGIC_ECD_nAChR_B2	25..228	CDD:349826	88/209 (42%)
		Cys-loop	149..163	CDD:349826	8/13 (62%)