Protein Alignment nAChRalpha5 and chrna4b

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001041528.1
• Gene: chrna4b / 556619
• ZFINID: ZDB-GENE-090505-3
• Length: 627
• Species: Danio rerio
• Alignment Length: 623
• Identity: 217/623 - (34%)
• Similarity: 307/623 - (49%)
• Gaps: 121/623 - (19%)

  Fly   292 SW--IFLL-IYLNLSAKVCLAGYH---EKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQII 350
            :|  .||| ::|.|:....::..|   |:|||..|...||.|.|||.|.||.:.:.|||::.|:|
Zfish     4 AWRVFFLLCVHLQLAYVFSMSPAHAHAEERLLQSLFINYNKLSRPVANISDVVLVHFGLSIAQLI 68

  Fly   351 DVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQT 415
            |||||||::.||||:|.||||..||||..:|..|..:|||...||:||:::||:||..|..|:.|
Zfish    69 DVDEKNQMMTTNVWVKQEWNDYKLRWNPEEYENVTSIRIPSEIIWRPDIVLYNNADGDFAVTHLT 133

  Fly   416 NVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSY 480
            ...|..||...:.||.|:||:|.||:|:||||.|.|:|||||||||..::|| :...:..|...|
Zfish   134 KAQVFYNGRIKWKPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDRAKIDL-ISMASDVDQMDY 197

  Fly   481 VLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLP 545
            ..:|||.::...|..|...|.||.|.|.|||::.||||..|:|..||||||:||:.:.:|.|.||
Zfish   198 WESGEWVIINAVGTYNIKKYECCTEIYPDITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLP 262

  Fly   546 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 610
            .:..||::|.:::||||||||.::.|.:|:||..:||:|.|....|..|..|::.|:.:||.|||
Zfish   263 SECAEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHR 327

  Fly   611 NADTHEMSEWIRIVFLCWLPWILRMSRPG-------------------------RPLILEF-PTT 649
            ::.||.|..|:|.:||..:|..|.|.||.                         |..||:. |.:
Zfish   328 SSRTHSMPHWVRQLFLHLVPRYLFMKRPPASGKRNCGKLIEMMHKQANSQSMFLRNNILDISPQS 392

  Fly   650 P---CSDTSSERKHQILSDVE-----------------LKERSSKSLLANVLDIDDDFRHNCR-- 692
            |   ...||:.::.|:..|..                 |:|.:|::....||.      :.|.
Zfish   393 PIPHLGPTSAAQQDQVQQDSTSPKPLFFCSSPSSQYSILQEENSQTPQTPVLS------YTCAYT 451

  Fly   693 -----------PMTPGGTLPH-------------------NPAFY---RTVYGQG---------- 714
                       |.|..|||.|                   ...|.   .:|.|.|
Zfish   452 NSIFASSTTSFPDTLLGTLLHTIPQDGAKSTECDFQGHSAESVFMEAKESVLGAGSCQHCLTSEG 516

  Fly   715 ------DDGSIGPIGSTRMPDAVTHHTCIKSSTE-----------YELGLILKEIRFITDQLRKD 762
                  |....|......||.|.........||:           ..|...|:.:::|.|.||.:
Zfish   517 TSLQKLDLDEAGRCTRHNMPSAQIFSPSSDGSTDLNAAEPVSNLSQSLLKALEGVQYIADHLRAE 581

  Fly   763 DECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800
            |....:..|||:.|||:||:.|.:|.:..||.|:.:.|
Zfish   582 DSDFSVREDWKYVAMVIDRIFLWMFVLVCILGTVGLFL 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	210/596 (35%)
chrna4b	NP_001041528.1	Neur_chan_LBD	31..237	CDD:280998	103/206 (50%)
		Neur_chan_memb	244..618	CDD:280999	103/379 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910