DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and chrna10a

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_021337092.1	Gene:	chrna10a / 556507	ZFINID:	ZDB-GENE-060503-725	Length:	532	Species:	Danio rerio

Alignment Length:	536	Identity:	186/536 - (34%)
Similarity:	295/536 - (55%)	Gaps:	35/536 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 NKHSWIF-LLIYLNLSAKVCLA--GYHEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLMQII 350
            :||...| ..:..::...||..  |.:.::||:||.:.|.:..|||.:..|.|.::..:||.|||
Zfish     3 HKHLQYFTFCVVCHMIIPVCWGANGIYAQKLLNDLFNNYTSALRPVEDTEDILNVTLQITLSQII 67

  Fly   351 DVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQT 415
            |:||:||:|...:|::..|.|..|.||..:|.|:..:|||...:|:||:::|||||:.|..|..|
Zfish    68 DMDERNQILTAYLWIRQVWIDKYLTWNKENYDGLDTIRIPGSYVWRPDIVLYNSADDHFTSTMDT 132

  Fly   416 NVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSY 480
            |||:|::|..::..|.|.||:||:|:::||||.|:|.:.:|||||:|.|||: |......|::..
Zfish   133 NVVIRHDGQIMWDAPAITKSSCKVDVSFFPFDAQQCRLTYGSWTYNGNQLDI-LNAMESADLADL 196

  Fly   481 VLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLP 545
            |.|.|||:||:|.|||.|.|.||.:||.|:|:.:.::||..:|.|||:||||:|:.:|.|||.||
Zfish   197 VDNVEWEVLGMPAKRNIILYGCCADPYPDVTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLP 261

  Fly   546 PDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHR 610
            .|||||:|||||::|:||||..:|||.|| .|:.|||:|.|:...|.|:.:|...||.::|.||.
Zfish   262 ADSGEKVSLGVTVMLALTVFQLLVAEIMP-PSENVPLIGKYYIATMTMITASTALTIFVMNIHHC 325

  Fly   611 NADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTP-----------CSDTSSERKHQILS 664
            ..|...:.:|.:...|.:|..|..:...|...:...|..|           |:......|...:.
Zfish   326 GPDAKPVPDWAKKFILQYLARICFVYEVGENCMTPQPEKPDPQPQKPQDCNCNMNGQAGKDDFVF 390

  Fly   665 DVEL-KERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQG-------DDGSI-- 719
            ..:. :|.:|..||       :|.....:.::|..:|..:|.....|:.:|       .||:.
Zfish   391 KFDRNQEATSPKLL-------EDREDMSQILSPACSLGKHPTCRYGVWKEGVFMSMDCGDGAAET 448

  Fly   720 -GPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLC 783
             .|||..: .....|.:..||..:.:...:|:.|.::.:..|..........:||..|.|:||..
Zfish   449 GKPIGRGQ-EGCRDHDSGFKSQCKCDQQHLLRNIEYVANCYRDQRATARRTGEWKKVAKVLDRFF 512

  Fly   784 LIIFTMFTILATIAVL 799
            :.:|.:.....::.::
Zfish   513 MWLFFIMVFFMSLLIM 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	180/509 (35%)
chrna10a	XP_021337092.1	Neur_chan_LBD	31..422	CDD:332142	159/399 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920