Protein Alignment nAChRalpha5 and chrna5

DIOPT Version :9

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001017885.1
• Gene: chrna5 / 550584
• ZFINID: ZDB-GENE-050417-440
• Length: 466
• Species: Danio rerio
• Alignment Length: 534
• Identity: 188/534 - (35%)
• Similarity: 277/534 - (51%)
• Gaps: 99/534 - (18%)

  Fly   292 SWIFLLIYLNLSAKVC-------LAGY--HEKRLLHDLLDPYNTLERPVLNESDPLQLSFGLTLM 347
            |.:..|:.|..||.:|       |:.|  .|.:|...|...|....||:.:.:..:|:.|||.:.
Zfish     6 SLVRALLPLVCSAVLCSAIGPPMLSSYAKTEDKLFKHLFSNYQKWVRPIEDLNTTIQVKFGLAIS 70

  Fly   348 QIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGT 412
            |::||||||||:.||||:|.||.|:.|||:...|.|:..:|:|...||.||:::|::||..|:.|
Zfish    71 QLVDVDEKNQLMTTNVWMKQEWTDLKLRWDPDHYLGITSIRVPSDSIWIPDIVLYDNADGNFEAT 135

  Fly   413 YQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDI 477
            . |..|||.:|:..:.||..:||.|.||:|:||||.|.|.||||||||||.|:|:.|:| ...|.
Zfish   136 V-TKAVVRFDGTISWTPPANYKSACTIDVTFFPFDLQNCSMKFGSWTYDGSQVDILLED-VHVDK 198

  Fly   478 SSYVLNGEWELLGVPG----KRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIPCVLIASMA 538
            ..|..|||||::...|    :|:..::      |..||::.||||..|:|...|||||:.::.:.
Zfish   199 RDYFDNGEWEIVKATGNRGLRRDGTFF------YPSITYSFIIRRLPLFYTLFLIIPCIGLSFLT 257

  Fly   539 LLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVSTIL 603
            :|.|.||.:.|||:||..::|:||||||.::.|.:|::|..:||:|.|....|..|..|:|.|:.
Zfish   258 VLVFYLPSNGGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIVITVF 322

  Fly   604 ILNYHHRNADT-HEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKHQILSDVE 667
            .:|.|||::.| |.|:.|:|.:||..||.:|.|                      |.|
Zfish   323 AINIHHRSSSTHHSMAPWVRRIFLHHLPRLLCM----------------------RSH------- 358

  Fly   668 LKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGSTRMPDAVT 732
                           :|       |..|..||        ||       |.:| .|.:...|.
Zfish   359 ---------------VD-------RYATSAGT--------RT-------GGLG-YGKSLSQDT-- 383

  Fly   733 HHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILAT-- 795
                .:...|:.|...|:.||:||..:.|::|..::..||||.|.|:||:.|..|.:.::|.:
Zfish   384 ----NQLDAEHNLQAALESIRYITRHVVKENEVREVVQDWKFVAQVLDRVFLWAFLLVSLLGSAL 444

  Fly   796 --IAVLLSAPHIIV 807
              |.|:.....|||
Zfish   445 LFIPVIYKWASIIV 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	177/497 (36%)
chrna5	NP_001017885.1	LIC	12..448	CDD:273305	181/516 (35%)
		Neur_chan_LBD	36..239	CDD:280998	92/210 (44%)
		Neur_chan_memb	246..446	CDD:280999	81/272 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910