Protein Alignment nAChRalpha5 and Chrnd

DIOPT Version :10

• Sequence 1: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_062171.1
• Gene: Chrnd / 54240
• RGDID: 2352
• Length: 517
• Species: Rattus norvegicus
• Alignment Length: 534
• Identity: 165/534 - (30%)
• Similarity: 264/534 - (49%)
• Gaps: 84/534 - (15%)

  Fly   300 LNLSAKVCLAG----YHEKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQL 358
            |.|.|.:.:.|    ..|:||:..|.:.  ||...|||..:.|.:.::..|||..:|.:.|..:.
  Rat     8 LGLLAALVVCGSWGLNEEQRLIQHLFEEKGYNKELRPVARKEDIVDVALSLTLSNLISLKEVEET 72

  Fly   359 LVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNG 423
            |.||||:...|.|..|:||.:::|.:..||:|...:|.|::::.|:.|..|..:|..||:|.::|
  Rat    73 LTTNVWIDHAWIDSRLQWNANEFGNITVLRLPSDMVWLPEIVLENNNDGSFQISYACNVLVSDSG 137

  Fly   424 SCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVL------ 482
            ...::||.||:|:|.|.:|:||||.|.|.:||.|..|...::.|.|:.|. .|..||.:
  Rat   138 HVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEIRLSLKQEE-EDNRSYPIEWIIID 201

  Fly   483 ------NGEWELLGVPGKRNEIYYNCCPEPYI--------DITFAIIIRRRTLYYFFNLIIPCVL 533
                  |||||::....|.|       .:|.:        |:||.:||||:.|:|..|:::||||
  Rat   202 PEGFTENGEWEIVHRAAKVN-------VDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVL 259

  Fly   534 IASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSV 598
            |:.|..|.|.||.|.|||.|:.:::||:.:|||.::::.:||||.|:||:|.:....|.:|...|
  Rat   260 ISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVV 324

  Fly   599 VSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGR----PLILEFPTTPCSDTSSERK 659
            |..:::||.|.|...||.:||.::..||..||.:|.||||..    |..|...|:.....|...:
  Rat   325 VICVIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSRPEEEDPGPRALIRRTSSLGYISKAEE 389

  Fly   660 HQIL---SDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGP 721
            :..|   ||:..:::|.:..||             |.:|
  Rat   390 YFSLKSRSDLMFEKQSERHGLA-------------RRLT-------------------------- 415

  Fly   722 IGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDRLCLII 786
              :.|.|.|.:..  ::.....|:...:....||.:.:|..:..|:..::|...|..||||||.:
  Rat   416 --TARKPPASSEQ--VQQELFNEMKPAVDGANFIVNHMRDQNSYNEEKDNWNQVARTVDRLCLFV 476

  Fly   787 FTMFTILATIAVLL 800
            .|...::.|..:.|
  Rat   477 VTPVMVVGTAWIFL 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	161/517 (31%)
Chrnd	NP_062171.1	LGIC_ECD	26..246	CDD:475126	77/227 (34%)
		Neur_chan_memb	253..489	CDD:460753	79/278 (28%)