DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha5 and Chrnb2

DIOPT Version :9

Sequence 1:	NP_001356885.1	Gene:	nAChRalpha5 / 34826	FlyBaseID:	FBgn0028875	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_062170.1	Gene:	Chrnb2 / 54239	RGDID:	2350	Length:	500	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	195/539 - (36%)
Similarity:	295/539 - (54%)	Gaps:	77/539 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 SGNSSSTQILNGLNKHSWIFLLIYLNLSAKVC---LAGYHEKRLLHDLLDP--YNTLERPVLNES 335
            :|:|:|..:.:        |.|::|      |   |....|:||:..||||  ||.|.||..|.|
  Rat     2 AGHSNSMALFS--------FSLLWL------CSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGS 52

  Fly   336 DPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNTSDYGGVKDLRIPPHRIWKPDVL 400
            :.:.:...::|.|:|.|.|:.|::.|||||..||.|..|.|...|:..:|.:|:|...||.|||:
  Rat    53 ELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVV 117

  Fly   401 MYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQL 465
            :||:||..::.::.:|.||..:||..::||.|:||.|||::..||||.|.|.|||.|||||..::
  Rat   118 LYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEI 182

  Fly   466 DLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIIP 530
            ||.|:.:. ..:..:..:|||:::.:||:|||   |.....|:|||:..||||:.|:|..|||||
  Rat   183 DLVLKSDV-ASLDDFTPSGEWDIIALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIP 243

  Fly   531 CVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVA 595
            ||||.|:|:|.|.||.|.|||::|.:::||:|||||.::::.:|.||..|||:|.|....|.:|.
  Rat   244 CVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVT 308

  Fly   596 SSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRMSRPGRPLILEFPTTPCSDTSSERKH 660
            .|:|:::.:||.|||:..||.|:.|:::|||..||.:|.:.:|                    :|
  Rat   309 FSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQP--------------------RH 353

  Fly   661 QILSD-VELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYG--------QGDD 716
            :.... :.|:.|..:...|..|    .||..  |.....|...|||..:.:.|        .|..
  Rat   354 RCARQRLRLRRRQREREGAGAL----FFREG--PAADPCTCFVNPASVQGLAGAFRAEPTAAGPG 412

  Fly   717 GSIGPIGSTRMPDAVTHHTCIKSSTEYELGLILKEIRFITDQLRKDDECNDIANDWKFAAMVVDR 781
            .|:||. |..:.:||                  ..:|||.|.:|.:|:...:..|||:.|||:||
  Rat   413 RSVGPC-SCGLREAV------------------DGVRFIADHMRSEDDDQSVREDWKYVAMVIDR 458

  Fly   782 LCLIIFTMFTILATIAVLL 800
            |.|.||....:..|:.:.|
  Rat   459 LFLWIFVFVCVFGTVGMFL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:273305	187/499 (37%)
Chrnb2	NP_062170.1	LIC	28..477	CDD:273305	186/497 (37%)
		Neur_chan_LBD	28..233	CDD:280998	90/208 (43%)
		Neur_chan_memb	240..476	CDD:280999	93/280 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910